Graduate University for Advanced Studies, Hayama, Kanagawa, Japan.
Université de Paris, Paris, France.
Bioessays. 2021 May;43(5):e2000233. doi: 10.1002/bies.202000233. Epub 2021 Feb 11.
With the ever-increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to counter-selection of such deleterious alleles. In reviewing this field, we speculate that a logical consequence would be the later occurrence of menopause and the extension of women's reproductive lifespan. We illustrate this point with a simple model that applies to other variants that contribute to female infertility, including epigenetic variation. We also consider the effect of medical interventions and lifestyle.
随着寿命的不断延长以及社会的变化，女性结婚和生育的时间比前几个世纪晚。然而，人群中分离出的致病性遗传变异会导致女性在正常绝经年龄之前出现生育能力下降或不孕，从而对这些有害等位基因进行反向选择。在回顾这一领域时，我们推测，合乎逻辑的结果将是绝经年龄的推迟和女性生育寿命的延长。我们用一个简单的模型来说明这一点，该模型适用于导致女性不孕的其他变体，包括表观遗传变异。我们还考虑了医疗干预和生活方式的影响。
