Gu Weikuan
Department of Orthopaedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Research Service, Memphis VA Medical Center, Memphis, Tennessee, USA.
Rejuvenation Res. 2022 Apr;25(2):110-115. doi: 10.1089/rej.2022.0017.
There are three major changes for the human lifespan in the past half decade: the decreased age of sexual maturity, slight increase in age of menopause/andropause, and a trend of increase in life expectancy. The ages of puberty and menopause are the transitions in life stages, such that early puberty leads to loss and late menopause leads to gain in the lifespan. So far, the strategies for increased lifespan have been largely focused on the postreproductive stage. These approaches are challenging and may at some point reach a plateau. It might be interesting to expand this focus to potentially delaying the puberty and extending the period of body growth, which might yield longer reproductive stages as well as the longer and healthier lifespan.
在过去的五年里，人类寿命有三个主要变化：性成熟年龄降低、绝经/男性更年期年龄略有增加以及预期寿命呈上升趋势。青春期和绝经年龄是生命阶段的转变，因此青春期早会导致寿命缩短，绝经晚会导致寿命延长。到目前为止，延长寿命的策略主要集中在生殖后期。这些方法具有挑战性，并且可能在某个时候达到极限。将关注点扩展到潜在地延迟青春期和延长身体生长时期可能会很有意思，这可能会带来更长的生殖阶段以及更长、更健康的寿命。
