Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Scar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, Yonsei University College of Medicine, Seoul, Korea.
J Cosmet Dermatol. 2021 Sep;20(9):2874-2879. doi: 10.1111/jocd.13993. Epub 2021 Feb 18.
Retinaldehyde is one of the major members of the retinoid family, which has potential skin rejuvenating effects on photoaged skin and has a good safety profile.
The study aimed to evaluate the efficacy and safety of multilamellar vesicle containing retinaldehyde (MLV-RAL) 0.05% and 0.1% used to treat photoaged skin.
A randomized, prospective, investigator-blinded, split-face comparison study was conducted. We enrolled 23 Korean volunteers who applied MLV-RAL 0.05%/0.1% cream on one randomized side of their face and retinol 0.05%/0.1% cream on the opposite side. Wrinkle depth on both crow's feet was assessed by the Antera 3D system. Skin hydration, elasticity, facial curved length, and dermal density were also evaluated.
After an 8-week application, all objective parameters, including wrinkle depth, were significantly improved in both MLV-RAL 0.05%/0.1% and retinol 0.05%/0.1% treated sides. Compared with the retinol-treated side, MLV-RAL-treated side showed a significant improvement of objective assessments except for dermal density. Additionally, there was no adverse event associated with the use of either MLV-RAL 0.05%/0.1% or retinol 0.05%/0.1% cream.
The application of MLV-RAL 0.05%/0.1% cream improved wrinkle, facial contour, and biophysical parameters associated with skin aging.
视黄醛是类视黄醇家族的主要成员之一，对光老化皮肤具有潜在的皮肤年轻化作用，且安全性良好。
本研究旨在评估含有视黄醛的多层囊泡（MLV-RAL）0.05%和 0.1%用于治疗光老化皮肤的疗效和安全性。
进行了一项随机、前瞻性、研究者盲法、分面比较研究。我们招募了 23 名韩国志愿者，他们将 MLV-RAL 0.05%/0.1%乳膏涂在一侧随机面部，将视黄醇 0.05%/0.1%乳膏涂在另一侧。通过 Antera 3D 系统评估鱼尾纹的皱纹深度。还评估了皮肤水分、弹性、面部弯曲长度和真皮密度。
在 8 周的应用后，MLV-RAL 0.05%/0.1%和视黄醇 0.05%/0.1%治疗侧的所有客观参数（包括皱纹深度）均显著改善。与视黄醇治疗侧相比，MLV-RAL 治疗侧除真皮密度外，所有客观评估均有显著改善。此外，使用 MLV-RAL 0.05%/0.1%或视黄醇 0.05%/0.1%乳膏均未发生不良反应。
MLV-RAL 0.05%/0.1%乳膏的应用改善了皱纹、面部轮廓和与皮肤老化相关的生物物理参数。
