Kang G, Tu T N T, Kim S, Yang H, Jang M, Jo D, Ryu J, Baek J, Jung H
Department of Biotechnology, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Juvic Inc., Building 102, Yonsei Engineering Research Park, 50, Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Int J Cosmet Sci. 2018 Apr;40(2):199-206. doi: 10.1111/ics.12453.
Although dissolving microneedle patches have been widely studied in the cosmetics field, no comparisons have been drawn with the topical applications available for routine use. In this study, two wrinkle-improving products, adenosine-loaded dissolving microneedle patches and an adenosine cream, were evaluated for efficacy, with respect to skin wrinkling, dermal density, elasticity, and hydration, and safety in a clinical test on the crow's feet area.
Clinical efficacy and safety tests were performed for 10 weeks on 22 female subjects with wrinkles around their eyes. The adenosine-loaded dissolving microneedle patch was applied once every 3 days, in the evening, for 8 weeks to the designated crow's feet area. The adenosine cream was applied two times per day, in the morning and evening, for 8 weeks to the other crow's feet area. Skin wrinkling, dermal density, elasticity, and hydration were measured by using PRIMOS premium, Dermascan C, Cutometer MPA580, and Corneometer CM 825, respectively. In addition, subjective skin irritation was evaluated by self-observation, and objective skin irritation was assessed through expert interviews.
The adenosine-loaded dissolving microneedle patches had a similar or better efficacy than the adenosine cream. Both groups showed statistically significant efficacy for almost all parameters (P < 0.05). The dissolving microneedle patches had a long-lasting effect on the average wrinkle depth (P < 0.05), only showed efficacy in dermal density (P < 0.05), had an early improving effect on elasticity (P < 0.05), and demonstrated better hydration efficacy (P < 0.001). No adverse effects were observed in either group during the test period.
In the clinical efficacy test of four skin-improvement parameters, adenosine-loaded dissolving microneedle patches showed the same or better effect than the adenosine cream, although the weekly adenosine dose was 140 times lower. The dissolving microneedle patches caused no adverse reactions. These adenosine-loaded dissolving microneedle patches are expected to be safe, effective, and novel cosmetics for skin improvement.
尽管溶蚀性微针贴片在化妆品领域已得到广泛研究，但尚未与常规使用的局部应用产品进行比较。在本研究中，对两种改善皱纹的产品，即载有腺苷的溶蚀性微针贴片和腺苷乳膏，在鱼尾纹区域进行了一项临床试验，评估了它们在皮肤皱纹、真皮密度、弹性和水合作用方面的功效以及安全性。
对22名有眼周皱纹的女性受试者进行了为期10周的临床疗效和安全性测试。载有腺苷的溶蚀性微针贴片每3天晚上在指定的鱼尾纹区域应用一次，持续8周。腺苷乳膏每天早晚在另一个鱼尾纹区域应用两次，持续8周。分别使用PRIMOS premium、Dermascan C、Cutometer MPA580和Corneometer CM 825测量皮肤皱纹、真皮密度、弹性和水合作用。此外，通过自我观察评估主观皮肤刺激，并通过专家访谈评估客观皮肤刺激。
载有腺苷的溶蚀性微针贴片的功效与腺苷乳膏相似或更好。两组在几乎所有参数上均显示出统计学上的显著功效（P < 0.05）。溶蚀性微针贴片对平均皱纹深度有持久影响（P < 0.05），仅在真皮密度方面显示出功效（P < 0.05），对弹性有早期改善作用（P < 0.05），并表现出更好的水合功效（P < 0.001）。在测试期间，两组均未观察到不良反应。
在四项皮肤改善参数的临床疗效测试中，载有腺苷的溶蚀性微针贴片显示出与腺苷乳膏相同或更好的效果，尽管每周的腺苷剂量低140倍。溶蚀性微针贴片未引起不良反应。这些载有腺苷的溶蚀性微针贴片有望成为安全、有效且新颖的皮肤改善化妆品。
