Marouan Laila, Hermansen Mette N, Hansen Kirsten Skamstrup, Chawes Bo
Ugeskr Laeger. 2021 Feb 1;183(5).
Delayed introduction of allergenic foods has failed to prevent the development of food allergy in children. This observation has led to randomised controlled trials of early introduction of allergenic foods. These trials are presented in this review. Early introduction of peanut in the LEAP and EAT trials and the introduction of cooked egg in PETIT and EAT was safe and significantly reduced challenge-proven peanut and egg allergy. Further studies are needed to explore the optimal age for introduction to different allergenic foods to reduce the prevalence of food allergy.
延迟引入致敏性食物未能预防儿童食物过敏的发生。这一观察结果促使开展了早期引入致敏性食物的随机对照试验。本综述介绍了这些试验。在LEAP试验和EAT试验中早期引入花生,以及在PETIT试验和EAT试验中引入熟鸡蛋都是安全的,并且显著降低了经激发试验证实的花生和鸡蛋过敏。需要进一步研究以探索引入不同致敏性食物的最佳年龄,以降低食物过敏的患病率。