Onizuka Kazumitsu, Ganbold Erchissaran, Ma Yue, Sasaki Shogo, Hazemi Madoka E, Chen Yutong, Sato Norihiro, Ozawa Mamiko, Nagasawa Kazuo, Nagatsugi Fumi
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
Org Biomol Chem. 2021 Apr 7;19(13):2891-2894. doi: 10.1039/d0ob02365e. Epub 2021 Feb 11.
The selective alkylation of nucleic acids is important for a medicinal approach and biological study. We now report a novel selective alkylation of the parallel G-quadruplex structure using the conjugate of the macrocyclic hexaoxazole L2G2-6OTD-1M1PA and vinyl-quinazolinone-S(O)Me (6OTD-VQ-S(O)Me).
核酸的选择性烷基化对于药物研发和生物学研究具有重要意义。我们现在报道一种使用大环六恶唑L2G2 - 6OTD - 1M1PA与乙烯基喹唑啉酮 - S(O)Me（6OTD - VQ - S(O)Me）的共轭物对平行G - 四链体结构进行的新型选择性烷基化反应。
