平行G-四链体结构的选择性烷基化
Selective alkylation of parallel G-quadruplex structure.
作者信息
Onizuka Kazumitsu, Ganbold Erchissaran, Ma Yue, Sasaki Shogo, Hazemi Madoka E, Chen Yutong, Sato Norihiro, Ozawa Mamiko, Nagasawa Kazuo, Nagatsugi Fumi
机构信息
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
出版信息
Org Biomol Chem. 2021 Apr 7;19(13):2891-2894. doi: 10.1039/d0ob02365e. Epub 2021 Feb 11.
The selective alkylation of nucleic acids is important for a medicinal approach and biological study. We now report a novel selective alkylation of the parallel G-quadruplex structure using the conjugate of the macrocyclic hexaoxazole L2G2-6OTD-1M1PA and vinyl-quinazolinone-S(O)Me (6OTD-VQ-S(O)Me).
核酸的选择性烷基化对于药物研发和生物学研究具有重要意义。我们现在报道一种使用大环六恶唑L2G2 - 6OTD - 1M1PA与乙烯基喹唑啉酮 - S(O)Me（6OTD - VQ - S(O)Me）的共轭物对平行G - 四链体结构进行的新型选择性烷基化反应。
Zotero 插件