Suppr超能文献

平行G-四链体结构的选择性烷基化

Selective alkylation of parallel G-quadruplex structure.

作者信息

Onizuka Kazumitsu, Ganbold Erchissaran, Ma Yue, Sasaki Shogo, Hazemi Madoka E, Chen Yutong, Sato Norihiro, Ozawa Mamiko, Nagasawa Kazuo, Nagatsugi Fumi

机构信息

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.

出版信息

Org Biomol Chem. 2021 Apr 7;19(13):2891-2894. doi: 10.1039/d0ob02365e. Epub 2021 Feb 11.

Abstract

The selective alkylation of nucleic acids is important for a medicinal approach and biological study. We now report a novel selective alkylation of the parallel G-quadruplex structure using the conjugate of the macrocyclic hexaoxazole L2G2-6OTD-1M1PA and vinyl-quinazolinone-S(O)Me (6OTD-VQ-S(O)Me).

摘要

核酸的选择性烷基化对于药物研发和生物学研究具有重要意义。我们现在报道一种使用大环六恶唑L2G2 - 6OTD - 1M1PA与乙烯基喹唑啉酮 - S(O)Me(6OTD - VQ - S(O)Me)的共轭物对平行G - 四链体结构进行的新型选择性烷基化反应。

相似文献

1
Selective alkylation of parallel G-quadruplex structure.
Org Biomol Chem. 2021 Apr 7;19(13):2891-2894. doi: 10.1039/d0ob02365e. Epub 2021 Feb 11.
2
G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer: greater selectivity than monomer.
Chem Commun (Camb). 2009 Nov 14(42):6481-3. doi: 10.1039/b910242f. Epub 2009 Sep 14.
3
Michael addition-activated alkylation of G-quadruplex DNA with methylamine-protected vinyl-quinazolinone derivatives.
Bioorg Med Chem Lett. 2024 Sep 1;109:129855. doi: 10.1016/j.bmcl.2024.129855. Epub 2024 Jun 20.
6
G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer.
Nucleic Acids Symp Ser (Oxf). 2009(53):233-4. doi: 10.1093/nass/nrp117.
7
Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using post-target-binding visualization.
Chem Commun (Camb). 2020 Nov 4;56(85):12905-12908. doi: 10.1039/d0cc04957c. Epub 2020 Oct 8.
8
Synthesis of a potent G-quadruplex-binding macrocyclic heptaoxazole.
Chembiochem. 2009 Feb 13;10(3):431-5. doi: 10.1002/cbic.200800563.
9
Macrocyclic polyoxazoles as G-quadruplex ligands.
Chem Rec. 2013 Dec;13(6):539-48. doi: 10.1002/tcr.201300015. Epub 2013 Nov 13.
10
Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds.
Biochimie. 2008 Aug;90(8):1233-49. doi: 10.1016/j.biochi.2008.03.011. Epub 2008 Apr 4.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验