大鼠神经上皮前体细胞在体内的增殖与分化
Proliferation and differentiation of rat neuroepithelial precursor cells in vivo.
作者信息
Frederiksen K, McKay R D
机构信息
Departments of Biology and Brain Science, Whitaker College, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
J Neurosci. 1988 Apr;8(4):1144-51. doi: 10.1523/JNEUROSCI.08-04-01144.1988.
Abstract
Important features of adult neuronal number, location, and type are a consequence of early embryonic events that occur before neurons have differentiated. We have measured cell number during embryogenesis of the rat CNS. Markers that are expressed in the proliferating neuronal precursor are required to study the mechanisms controlling their proliferation and differentiation. By applying immunohistochemistry, fluorescence-activated cell sorting, and 3H-thymidine auto-radiography to dissociated rat CNS cells, we show that the monoclonal antibody Rat 401 recognizes a cell population with proliferative, temporal, and quantitative features expected of neuronal precursors.
摘要
成年神经元数量、位置和类型的重要特征是在神经元分化之前发生的早期胚胎事件的结果。我们已经测量了大鼠中枢神经系统胚胎发生过程中的细胞数量。研究控制其增殖和分化机制需要在增殖的神经元前体中表达的标志物。通过对解离的大鼠中枢神经系统细胞应用免疫组织化学、荧光激活细胞分选和3H-胸腺嘧啶自动放射自显影技术，我们发现单克隆抗体Rat 401识别的细胞群体具有神经元前体预期的增殖、时间和定量特征。
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