Thibodeau L L, Ariza A, Piepmeier J M
Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.
J Neurosurg. 1988 May;68(5):802-5. doi: 10.3171/jns.1988.68.5.0802.
This report describes a case of primary leptomeningeal sarcomatosis in a 50-year-old man who presented with progressive deficits involving multiple cranial nerves and spinal roots. Despite the clinical evidence supporting a diffuse process involving the leptomeninges, radiological, serological, and cerebrospinal fluid examinations failed to reveal the cause of the disorder. Consequently, surgical exploration and biopsy were required to obtain a pathological diagnosis. This case report illustrates the difficulty in diagnosing this disease and supports the use of open biopsy in patients with chronic meningeal disease when the diagnosis cannot be established by less invasive methods.
本报告描述了一名50岁男性原发性柔脑膜肉瘤病的病例，该患者出现涉及多条颅神经和脊神经根的进行性功能缺损。尽管有临床证据支持柔脑膜存在弥漫性病变，但影像学、血清学和脑脊液检查均未能揭示该疾病的病因。因此，需要进行手术探查和活检以获得病理诊断。本病例报告说明了诊断这种疾病的困难，并支持在采用侵入性较小的方法无法确诊时，对患有慢性脑膜疾病的患者进行开放性活检。
