Brown J T, Hulka B S
Division of General Internal Medicine, Duke University Medical Center, Durham, NC 27706.
J Gen Intern Med. 1988 Mar-Apr;3(2):126-31. doi: 10.1007/BF02596116.
This case-control study tested the hypothesis that elderly women with metastatic breast cancer were previously screened less than controls. Cases included women over 60 years old who had metastatic breast cancer; the tumor registry provided controls. Identical criteria yielded comparable groups (cases = 109, controls = 211) receiving primary care at this tertiary center. Radiology and medical records were examined for mammograms; these were blindly categorized "diagnostic," "screening," or "indeterminant." The major, unexpected finding was that less than 6% of controls had ever had screening mammography. The associations between screening and metastatic cancer (odds ratios) suggest a beneficial effect of screening: OR/0.73 for ever screened and OR/0.71 if screened within the year of cancer diagnosis. All confidence intervals include one; however, low screening participation leaves this study with little power. The major implication is that despite the current recommendations, the elderly are not being included in screening mammography programs.
患有转移性乳腺癌的老年女性此前接受筛查的次数少于对照组。病例包括60岁以上患有转移性乳腺癌的女性;肿瘤登记处提供了对照组。相同的标准产生了在该三级中心接受初级护理的可比组(病例 = 109,对照 = 211)。检查放射学和医疗记录以查看乳房X光片;这些被盲目分类为“诊断性”、“筛查性”或“不确定”。主要的意外发现是,不到6%的对照组女性曾接受过筛查性乳房X光检查。筛查与转移性癌症之间的关联(比值比)表明筛查有有益效果:曾接受筛查的比值比为0.73,在癌症诊断当年接受筛查的比值比为0.71。所有置信区间都包含1;然而,筛查参与率低使得这项研究几乎没有效力。主要的影响是,尽管有当前的建议,但老年人并未被纳入筛查性乳房X光检查项目。