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老年女性乳腺钼靶筛查:一项病例对照研究。

Screening mammography in the elderly: a case-control study.

作者信息

Brown J T, Hulka B S

机构信息

Division of General Internal Medicine, Duke University Medical Center, Durham, NC 27706.

出版信息

J Gen Intern Med. 1988 Mar-Apr;3(2):126-31. doi: 10.1007/BF02596116.

Abstract

This case-control study tested the hypothesis that elderly women with metastatic breast cancer were previously screened less than controls. Cases included women over 60 years old who had metastatic breast cancer; the tumor registry provided controls. Identical criteria yielded comparable groups (cases = 109, controls = 211) receiving primary care at this tertiary center. Radiology and medical records were examined for mammograms; these were blindly categorized "diagnostic," "screening," or "indeterminant." The major, unexpected finding was that less than 6% of controls had ever had screening mammography. The associations between screening and metastatic cancer (odds ratios) suggest a beneficial effect of screening: OR/0.73 for ever screened and OR/0.71 if screened within the year of cancer diagnosis. All confidence intervals include one; however, low screening participation leaves this study with little power. The major implication is that despite the current recommendations, the elderly are not being included in screening mammography programs.

摘要

这项病例对照研究检验了这样一个假设

患有转移性乳腺癌的老年女性此前接受筛查的次数少于对照组。病例包括60岁以上患有转移性乳腺癌的女性;肿瘤登记处提供了对照组。相同的标准产生了在该三级中心接受初级护理的可比组(病例 = 109,对照 = 211)。检查放射学和医疗记录以查看乳房X光片;这些被盲目分类为“诊断性”、“筛查性”或“不确定”。主要的意外发现是,不到6%的对照组女性曾接受过筛查性乳房X光检查。筛查与转移性癌症之间的关联(比值比)表明筛查有有益效果:曾接受筛查的比值比为0.73,在癌症诊断当年接受筛查的比值比为0.71。所有置信区间都包含1;然而,筛查参与率低使得这项研究几乎没有效力。主要的影响是,尽管有当前的建议,但老年人并未被纳入筛查性乳房X光检查项目。

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