O'Malley M S, Fletcher S W
JAMA. 1987 Apr 24;257(16):2196-203.
We reviewed evidence regarding breast self-examination (BSE) and screening for breast cancer. To our knowledge, no controlled prospective trial links BSE to lives saved from breast cancer. Compared with clinical breast examination and mammography, the estimated sensitivity of BSE is low (20% to 30%) and is lower among older women. The potential sensitivity of BSE should be higher because women can detect small lumps (0.3 cm) in silicone models. Instruction increases BSE frequency over the short term. Sensitivity also increases, but specificity decreases. The psychological effects of teaching and performing BSE are not yet clear. The cost of screening by BSE is unknown but depends on the accuracy of the test as well as the training method used. Breast self-examination has potential as a screening test for breast cancer, but many questions require scientific examination before this procedure can be advocated as a screening test for breast cancer.
我们回顾了有关乳房自我检查(BSE)及乳腺癌筛查的证据。据我们所知,尚无对照前瞻性试验将乳房自我检查与因乳腺癌而挽救的生命联系起来。与临床乳房检查和乳房X光检查相比,乳房自我检查的估计敏感度较低(20%至30%),且在老年女性中更低。乳房自我检查的潜在敏感度本应更高,因为女性能够在硅胶模型中检测到小肿块(0.3厘米)。指导在短期内会增加乳房自我检查的频率。敏感度也会增加,但特异度会降低。教授和进行乳房自我检查的心理影响尚不清楚。通过乳房自我检查进行筛查的成本未知,但取决于检测的准确性以及所采用的培训方法。乳房自我检查有作为乳腺癌筛查测试的潜力,但在将此程序倡导为乳腺癌筛查测试之前,许多问题需要进行科学检验。