Department of Anatomical Sciences, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Int J Dev Neurosci. 2021 May;81(3):221-228. doi: 10.1002/jdn.10096. Epub 2021 Feb 18.
Autism Spectrum Disorders (ASDs) are common neurodevelopmental disorders with a growing incidence that generally present in the first 3 years of life. Behavioral symptoms, including impaired social interaction and increased repetitive or stereotypic movements, are hallmark characteristics of autism. Animal models are research tools used to study the biology of the disease and to develop new therapeutic approaches. The complexity of the etiology of autism makes it challenging to develop a comprehensive animal model that accurately mimics different clinical aspects of autism. Here, we reviewed the literature on modeling and behavioral assessment of autism in the rodent, and focused on ASD behavioral phenotypes that can be modeled in rodents. These animal models can be effective in gaining a better understanding of the pathophysiology of the disease.
自闭症谱系障碍（ASD）是一种常见的神经发育障碍，发病率不断上升，通常在生命的头 3 年出现。行为症状，包括社交互动障碍和重复性或刻板性运动增加，是自闭症的显著特征。动物模型是用于研究疾病生物学和开发新治疗方法的研究工具。自闭症病因的复杂性使得开发一种能够准确模拟自闭症不同临床方面的综合动物模型具有挑战性。在这里，我们回顾了啮齿动物自闭症模型和行为评估的文献，并重点介绍了可以在啮齿动物中建模的自闭症行为表型。这些动物模型可以有效地帮助我们更好地了解疾病的病理生理学。
