Cortés Yamnia I, Brooks Maria, Barinas-Mitchell Emma, Matthews Karen A, Thurston Rebecca C, Catov Janet M
School of Nursing, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA.
Menopause. 2021 Feb 8;28(3):255-262. doi: 10.1097/GME.0000000000001739.
To examine whether blood pressure (BP) accelerates more rapidly during the menopause transition for women with a history of preterm or term small for gestational age (SGA) delivery compared to women with all term and appropriate for gestational age (AGA) births.
A longitudinal analysis was conducted with 1,008 parous women who had BP data at ≥2 study visits. We used generalized linear modeling to examine BP before the final menstrual period, at the final mentrual period, and up to 10 years after the final menstrual period, according to pregnancy group. We assessed maternal changes in BP over time in relation to years near the final menstrual period using a piece-wise linear model, consistent with menopause-induced changes. Models were adjusted for socio-demographics, body mass index, smoking, physical activity, medications, parity, age at first birth, gestational diabetes, and gestational hypertension/preeclampsia.
At baseline, women were on average 46 years old, 101 (10%) reported a prior preterm birth, and 102 (10.1%) reported a term SGA birth. Compared to women with all term AGA births, women with a term SGA birth had higher BP before the final menstrual period, at the final menstrual period, and up to 10 years after the final menstrual period; women with a preterm birth had higher BP in the postmenopausal years. Annual rate of change in BP during the menopause transition did not differ between pregnancy groups.
Women with a history preterm and term SGA delivery have higher BP than women with all term AGA births during the menopause transition, but rate of change in BP does not differ in these groups relative to final menstrual period.
探讨与足月且适于胎龄（AGA）出生的女性相比，有早产或足月小于胎龄（SGA）分娩史的女性在绝经过渡期间血压（BP）升高是否更快。
对1008名经产妇进行纵向分析，这些女性在≥2次研究访视时均有血压数据。我们使用广义线性模型，根据妊娠组来检查末次月经前、末次月经时以及末次月经后长达10年的血压情况。我们使用分段线性模型评估了与末次月经临近年份相关的母亲血压随时间的变化，这与绝经引起的变化一致。模型对社会人口统计学因素、体重指数、吸烟、身体活动、药物治疗、产次、初产年龄、妊娠期糖尿病以及妊娠期高血压/子痫前期进行了校正。
在基线时，女性平均年龄为46岁，101名（10%）报告有早产史，102名（10.1%）报告有足月SGA分娩史。与所有足月AGA分娩的女性相比，足月SGA分娩的女性在末次月经前、末次月经时以及末次月经后长达10年的血压更高；早产的女性在绝经后几年血压更高。绝经过渡期间血压的年变化率在妊娠组之间没有差异。
有早产和足月SGA分娩史的女性在绝经过渡期间的血压高于所有足月AGA分娩的女性，但这些组中相对于末次月经的血压变化率没有差异。
