Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, RI, USA.
Department of Neurology, Brown University, Providence, RI, USA.
Behav Brain Res. 2021 Apr 23;404:113153. doi: 10.1016/j.bbr.2021.113153. Epub 2021 Feb 8.
The cortical role of the motor symptoms reflected by kinematic characteristics in Parkinson's disease (PD) is poorly understood. In this study, we aim to explore how PD affects cortico-kinematic interactions. Electroencephalographic (EEG) and kinematic data were recorded from seven healthy participants and eight participants diagnosed with PD during a set of self-paced finger tapping tasks. Event-related desynchronization (ERD) was compared between groups in the α (8-14 Hz), low-ß (14-20 Hz), and high-ß (20-35 Hz) frequency bands to investigate between-group differences in the cortical activities associated with movement. Average kinematic peak amplitudes and latencies were extracted alongside Sample Entropy (SaEn), a measure of signal complexity, as variables for comparison between groups. These variables were further correlated with average EEG power in each frequency band to establish within-group interactions between cortical motor functions and kinematic motor output. High ß-band power correlated with mean kinematic peak latency and signal complexity in the healthy group, while no correlation was found in the PD group. Also, the healthy group demonstrated stronger ERD in the broad ß-band than the PD participants. Our results suggest that cortical ß-band power in healthy populations is graded to finger tapping latency and complexity of movement, but this relationship is impaired in PD. These insights could help further enhance our understanding of the role of cortical ß-band oscillations in healthy movement and the possible disruption of that relationship in PD. These outcomes can provide further directions for treatment and therapeutic applications and potentially establish cortical biomarkers of Parkinson's disease.
运动症状的皮质作用反映了帕金森病（PD）的运动学特征，但人们对此知之甚少。在这项研究中，我们旨在探讨 PD 如何影响皮质-运动相互作用。在一组自我调节的手指敲击任务中，从七名健康参与者和八名被诊断为 PD 的参与者中记录了脑电图（EEG）和运动学数据。在α（8-14 Hz）、低β（14-20 Hz）和高β（20-35 Hz）频段比较组间的事件相关去同步（ERD），以研究与运动相关的皮质活动的组间差异。提取平均运动学峰值幅度和潜伏期，以及信号复杂度的度量样本熵（SaEn），作为组间比较的变量。这些变量进一步与每个频带的平均 EEG 功率相关联，以建立皮质运动功能与运动学运动输出之间的组内相互作用。高β频段的功率与健康组的平均运动学峰值潜伏期和信号复杂度相关，而 PD 组则没有相关性。此外，健康组在广泛的β频段表现出比 PD 参与者更强的 ERD。我们的结果表明，健康人群的皮质β频段功率与手指敲击潜伏期和运动复杂度相关，但这种关系在 PD 中受损。这些见解有助于进一步加深我们对皮质β频段振荡在健康运动中的作用以及这种关系在 PD 中可能中断的理解。这些结果可以为治疗和治疗应用提供进一步的方向，并有可能建立帕金森病的皮质生物标志物。
