Division of Biostatistics, Department of Population Health, NYU Grossman School of Medicine (NYUGSOM), New York University, New York, NY 10016, USA.
Department of Environmental Medicine, NYUG-SOM, New York University, New York, NY 10016, USA.
Int J Environ Res Public Health. 2021 Feb 9;18(4):1646. doi: 10.3390/ijerph18041646.
(1) Recent studies have reported elevated risks of multiple cancers in the World Trade Center (WTC) affected community members (also called WTC "Survivors"). The large variety of WTC-cancers created a need to develop a comprehensive cancer database. This paper describes the development of a pan-cancer database at the WTC Environmental Health Center (EHC) Data Center. (2) A new REDCap-based pan-cancer database was created using the pathology reports and available biomarker data of confirmed cancer cases after review by a cancer epidemiologist, a pathologist, physicians and biostatisticians. (3) The WTC EHC pan-cancer database contains cancer characteristics and emerging biomarker information for cancers of individuals enrolled in the WTC EHC and diagnosed after 11 September 2001 and up to 31 December 2019 obtained from WTC EHC clinical records, pathological reports and state cancer registries. As of 31 December 2019, the database included 3440 cancer cases with cancer characteristics and biomarker information. (4) This evolving database represents an important resource for the scientific community facilitating future research about the etiology, heterogeneity, characteristics and outcomes of cancers and comorbid mental health conditions, cancer economics and gene-environment interaction in the unique population of WTC survivors.
（1） 最近的研究报告称，在世贸中心（WTC）受影响社区成员（也称为 WTC“幸存者”）中，多种癌症的风险增加。WTC 癌症的种类繁多，因此需要开发一个综合癌症数据库。本文描述了在世贸中心环境健康中心（EHC）数据中心开发一个泛癌症数据库的情况。（2） 使用经过癌症流行病学家、病理学家、医生和生物统计学家审查的确诊癌症病例的病理报告和可用生物标志物数据，在 REDCap 基础上创建了一个新的泛癌症数据库。（3） WTC EHC 泛癌症数据库包含 2001 年 9 月 11 日以后在世贸中心 EHC 登记并被诊断为癌症的个人的癌症特征和新兴生物标志物信息，这些信息来自世贸中心 EHC 临床记录、病理报告和州癌症登记处。截至 2019 年 12 月 31 日，该数据库包含 3440 例癌症病例，具有癌症特征和生物标志物信息。（4） 这个不断发展的数据库代表了科学界的一个重要资源，有助于未来研究 WTC 幸存者这一独特人群中的癌症病因、异质性、特征和结果以及合并的心理健康状况、癌症经济学和基因-环境相互作用。
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