Jacob Ysabel, Anderton Ryan S, Cochrane Wilkie Jodie L, Rogalski Brent, Laws Simon M, Jones Anthony, Spiteri Tania, Hart Nicolas H
School of Medical and Health Sciences, Edith Cowan University, Perth 6027, Australia.
Institute for Health Research, University of Notre Dame Australia, Perth 6160, Australia.
Sports (Basel). 2021 Jan 29;9(2):22. doi: 10.3390/sports9020022.
Genetic variants in the () (rs4343), () (rs1815739), () (rs1801253), and () (rs8192678) genes have previously been associated with elite athletic performance. This study assessed the influence of polymorphisms in these candidate genes towards endurance test performance in 46 players from a single Australian Football League (AFL) team. Each player provided saliva buccal swab samples for DNA analysis and genotyping and were required to perform two independent two-kilometre running time-trials, six weeks apart. Linear mixed models were created to account for repeated measures over time and to determine whether player genotypes are associated with overall performance in the two-kilometre time-trial. The results showed that the CC ( = 0.034) and GG ( = 0.031) genotypes were significantly associated with a faster two-kilometre time-trial. This is the first study to link genetic polymorphism to an assessment of endurance performance in Australian Football and provides justification for further exploratory or confirmatory studies.
此前，（）（rs4343）、（）（rs1815739）、（）（rs1801253）和（）（rs8192678）基因中的遗传变异已被证明与精英运动表现相关。本研究评估了这些候选基因中的多态性对来自澳大利亚一个足球联盟（AFL）球队的46名球员耐力测试表现的影响。每位球员都提供了唾液颊拭子样本用于DNA分析和基因分型，并被要求在六周的间隔内进行两次独立的两公里跑步计时赛。构建线性混合模型以考虑随时间的重复测量，并确定球员基因型是否与两公里计时赛的整体表现相关。结果显示，CC（=0.034）和GG（=0.031）基因型与更快的两公里计时赛显著相关。这是第一项将基因多态性与澳大利亚足球耐力表现评估联系起来的研究，并为进一步的探索性或验证性研究提供了依据。
