Massidda Myosotis, Bachis Valeria, Corrias Laura, Piras Francesco, Scorcu Marco, Culigioni Claudia, Masala Daniele, Calò Carla M
Department of Life and Environmental Sciences, University of Cagliari, SS 554, km 4.500, Monserrato, 09042, Italy.
FMSI CR Sardegna and Cagliari Calcio SpA, Viale Tiziano, Cagliari, 70-00196, Italy.
Sports Med Open. 2015 Dec;1(1):6. doi: 10.1186/s40798-015-0008-x. Epub 2015 Mar 27.
The ACTN3 gene may influence performance in team sports, in which sprint action and high-speed movements, regulated by the anaerobic energy system, are crucial to the ultimate success of a match. The aim of this study was to determine the association between the ACTN3 R577X (rs1815739) polymorphism and elite team sport athletic status in Italian male athletes.
We compared the genotype and allele frequency of the ACTN3 R577X polymorphism between team sport athletes (n = 75), endurance athletes (n = 40), sprint/power athletes (n = 64), and non-athletic healthy controls (n = 192) from Italy. Genomic DNA was collected using a buccal swab. Extraction was performed according to the manufacturer's directions provided with a commercially available kit (Qiagen S.r.l., Milan, Italy).
Team sport athletes showed a lower frequency of the 577RR genotype compared to the 577XX genotype than sprint/power athletes (p = 0.044). However, the ACTN3 R577X polymorphism was not associated with team sport athletic status compared to endurance athletes and non-athletic controls.
Our results agree with a recent large-scale study involving athletes from Spain, Poland, and Russia. The ACTN3 R577X polymorphism was not associated with team sport athletic status compared to endurance athletes and non-athletic controls.
α-辅肌动蛋白3（ACTN3）基因可能会影响团队运动的表现，在团队运动中，由无氧能量系统调节的冲刺动作和高速运动对比赛的最终胜利至关重要。本研究的目的是确定ACTN3基因R577X（rs1815739）多态性与意大利男性运动员的精英团队运动竞技状态之间的关联。
我们比较了来自意大利的团队运动运动员（n = 75）、耐力运动员（n = 40）、短跑/力量型运动员（n = 64）和非运动员健康对照组（n = 192）之间ACTN3基因R577X多态性的基因型和等位基因频率。使用口腔拭子收集基因组DNA。按照随市售试剂盒（意大利米兰Qiagen S.r.l.公司）提供的制造商说明进行提取。
与短跑/力量型运动员相比，团队运动运动员中577RR基因型的频率低于577XX基因型（p = 0.044）。然而，与耐力运动员和非运动员对照组相比，ACTN3基因R577X多态性与团队运动竞技状态无关。
我们的结果与最近一项涉及来自西班牙、波兰和俄罗斯运动员的大规模研究一致。与耐力运动员和非运动员对照组相比，ACTN3基因R577X多态性与团队运动竞技状态无关。
