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1
The ACTN3 R577X polymorphism is associated with muscle power in male Japanese athletes.α-辅肌动蛋白3基因R577X多态性与日本男性运动员的肌肉力量有关。
J Strength Cond Res. 2014 Jul;28(7):1783-9. doi: 10.1519/JSC.0000000000000338.
2
ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling.ACTN3 基因型通过调节钙调神经磷酸酶信号通路影响肌肉性能。
J Clin Invest. 2013 Oct;123(10):4255-63. doi: 10.1172/JCI67691. Epub 2013 Sep 16.
3
ACTN3 R577X genotype is associated with sprinting in elite Japanese athletes.ACTN3 R577X 基因型与日本精英运动员的短跑表现有关。
Int J Sports Med. 2014 Feb;35(2):172-7. doi: 10.1055/s-0033-1347171. Epub 2013 Jul 18.
4
ACTN3 R577X polymorphism and explosive leg-muscle power in elite basketball players.ACTN3 R577X 多态性与精英篮球运动员腿部肌肉爆发力的关系。
Int J Sports Physiol Perform. 2014 Mar;9(2):226-32. doi: 10.1123/ijspp.2012-0331. Epub 2013 May 20.
5
Genes for elite power and sprint performance: ACTN3 leads the way.精英力量和短跑表现的基因：ACTN3 引领潮流。
Sports Med. 2013 Sep;43(9):803-17. doi: 10.1007/s40279-013-0059-4.
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Effect of ACTN3 gene on strength and endurance in soccer players.ACTN3 基因对足球运动员力量和耐力的影响。
J Strength Cond Res. 2013 Dec;27(12):3286-92. doi: 10.1519/JSC.0b013e3182915e66.
7
ACTN3 R577X polymorphism and team-sport performance: a study involving three European cohorts.ACTN3 R577X 多态性与团队运动表现：涉及三个欧洲队列的研究。
J Sci Med Sport. 2014 Jan;17(1):102-6. doi: 10.1016/j.jsams.2013.02.005. Epub 2013 Mar 21.
8
The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis.运动表现与 ACE 和 ACTN3 基因多态性的关联：系统评价和荟萃分析。
PLoS One. 2013;8(1):e54685. doi: 10.1371/journal.pone.0054685. Epub 2013 Jan 24.
9
Association analysis of ACE and ACTN3 in elite Caucasian and East Asian swimmers.ACE 和 ACTN3 基因多态性与优秀白种人和东亚游泳运动员的关联分析。
Med Sci Sports Exerc. 2013 May;45(5):892-900. doi: 10.1249/MSS.0b013e31827c501f.
10
Genetic markers and explosive leg-muscle strength in elite Italian soccer players.意大利精英足球运动员的基因标记与爆发性腿部肌肉力量
J Sports Med Phys Fitness. 2012 Jun;52(3):328-34.

α-辅肌动蛋白3基因R577X多态性与意大利团队运动运动员的运动状态无关。

ACTN3 R577X polymorphism is not associated with team sport athletic status in Italians.

作者信息

Massidda Myosotis, Bachis Valeria, Corrias Laura, Piras Francesco, Scorcu Marco, Culigioni Claudia, Masala Daniele, Calò Carla M

机构信息

Department of Life and Environmental Sciences, University of Cagliari, SS 554, km 4.500, Monserrato, 09042, Italy.

FMSI CR Sardegna and Cagliari Calcio SpA, Viale Tiziano, Cagliari, 70-00196, Italy.

出版信息

Sports Med Open. 2015 Dec;1(1):6. doi: 10.1186/s40798-015-0008-x. Epub 2015 Mar 27.

DOI:10.1186/s40798-015-0008-x
PMID:27747845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4532716/
Abstract

BACKGROUND

The ACTN3 gene may influence performance in team sports, in which sprint action and high-speed movements, regulated by the anaerobic energy system, are crucial to the ultimate success of a match. The aim of this study was to determine the association between the ACTN3 R577X (rs1815739) polymorphism and elite team sport athletic status in Italian male athletes.

METHODS

We compared the genotype and allele frequency of the ACTN3 R577X polymorphism between team sport athletes (n = 75), endurance athletes (n = 40), sprint/power athletes (n = 64), and non-athletic healthy controls (n = 192) from Italy. Genomic DNA was collected using a buccal swab. Extraction was performed according to the manufacturer's directions provided with a commercially available kit (Qiagen S.r.l., Milan, Italy).

RESULTS

Team sport athletes showed a lower frequency of the 577RR genotype compared to the 577XX genotype than sprint/power athletes (p = 0.044). However, the ACTN3 R577X polymorphism was not associated with team sport athletic status compared to endurance athletes and non-athletic controls.

CONCLUSIONS

Our results agree with a recent large-scale study involving athletes from Spain, Poland, and Russia. The ACTN3 R577X polymorphism was not associated with team sport athletic status compared to endurance athletes and non-athletic controls.

摘要

背景

α-辅肌动蛋白3（ACTN3）基因可能会影响团队运动的表现，在团队运动中，由无氧能量系统调节的冲刺动作和高速运动对比赛的最终胜利至关重要。本研究的目的是确定ACTN3基因R577X（rs1815739）多态性与意大利男性运动员的精英团队运动竞技状态之间的关联。

方法

我们比较了来自意大利的团队运动运动员（n = 75）、耐力运动员（n = 40）、短跑/力量型运动员（n = 64）和非运动员健康对照组（n = 192）之间ACTN3基因R577X多态性的基因型和等位基因频率。使用口腔拭子收集基因组DNA。按照随市售试剂盒（意大利米兰Qiagen S.r.l.公司）提供的制造商说明进行提取。

结果

与短跑/力量型运动员相比，团队运动运动员中577RR基因型的频率低于577XX基因型（p = 0.044）。然而，与耐力运动员和非运动员对照组相比，ACTN3基因R577X多态性与团队运动竞技状态无关。

结论

我们的结果与最近一项涉及来自西班牙、波兰和俄罗斯运动员的大规模研究一致。与耐力运动员和非运动员对照组相比，ACTN3基因R577X多态性与团队运动竞技状态无关。