Nikolopoulou Pinelopi A, Koufaki Maria A, Kostourou Vassiliki
Biomedical Sciences Research Centre "Alexander Fleming", Institute of Bioinnovation, 34 Fleming Str., 16672 Vari-Athens, Greece.
Cancers (Basel). 2021 Jan 30;13(3):525. doi: 10.3390/cancers13030525.
Beyond the conventional perception of solid tumours as mere masses of cancer cells, advanced cancer research focuses on the complex contributions of tumour-associated host cells that are known as "tumour microenvironment" (TME). It has been long appreciated that the tumour stroma, composed mainly of blood vessels, cancer-associated fibroblasts and immune cells, together with the extracellular matrix (ECM), define the tumour architecture and influence cancer cell properties. Besides soluble cues, that mediate the crosstalk between tumour and stroma cells, cell adhesion to ECM arises as a crucial determinant in cancer progression. In this review, we discuss how adhesome, the intracellular protein network formed at cell adhesions, regulate the TME and control malignancy. The role of adhesome extends beyond the physical attachment of cells to ECM and the regulation of cytoskeletal remodelling and acts as a signalling and mechanosensing hub, orchestrating cellular responses that shape the tumour milieu.
除了将实体瘤传统地视为仅仅是癌细胞团块之外，先进的癌症研究聚焦于被称为“肿瘤微环境”（TME）的肿瘤相关宿主细胞的复杂作用。长期以来人们已经认识到，主要由血管、癌症相关成纤维细胞和免疫细胞组成的肿瘤基质，连同细胞外基质（ECM），决定了肿瘤结构并影响癌细胞特性。除了介导肿瘤细胞与基质细胞间相互作用的可溶性信号外，细胞与ECM的黏附成为癌症进展的一个关键决定因素。在本综述中，我们讨论在细胞黏附处形成的细胞内蛋白质网络——黏附体如何调节肿瘤微环境并控制恶性肿瘤。黏附体的作用不仅限于细胞与ECM的物理附着以及细胞骨架重塑的调节，它还作为一个信号传导和机械传感中心，协调塑造肿瘤微环境的细胞反应。
