Department for Visceral Surgery and Medicine, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland.
Department for BioMedical Research (DBMR), Bern University Hospital, University of Bern, CH-3008 Bern, Switzerland.
Int J Mol Sci. 2021 Jan 30;22(3):1412. doi: 10.3390/ijms22031412.
Recent studies have helped to increase the understanding of the function of Connexin-43 (Cx43) in macrophages (Mφ). The various roles of Cx43 in Mφs range from migration, antigen-presentation and some forms of intercellular communication to more delicate processes, such as electrochemical support in the propagation of the heartbeat, immunomodulatory regulation in the lungs and in macrophage-differentiation. Its relevance in pathophysiology becomes evident in inflammatory bowel disease (IBD), tumours and HIV, in which aberrant functioning of Cx43 has been described. However, the involvement of Cx43 in other Mφ functions, such as phagocytosis and polarisation, and its involvement in other types of local and systemic inflammation, are still unclear and need further research.
最近的研究有助于增加对连接蛋白 43(Cx43)在巨噬细胞(Mφ)中功能的理解。Cx43 在 Mφ 中的各种作用范围从迁移、抗原呈递和一些形式的细胞间通讯到更精细的过程,如在心跳传播中的电化学支持、在肺部和巨噬细胞分化中的免疫调节调节。它在炎症性肠病(IBD)、肿瘤和 HIV 中的生理病理学相关性变得明显,其中已经描述了 Cx43 的异常功能。然而,Cx43 参与其他巨噬细胞功能,如吞噬作用和极化作用,以及其参与其他类型的局部和全身炎症,仍然不清楚,需要进一步研究。