Ma Liang, Wang Wenzhao, Xu Guixuan, Li Hao, Liu Fei, Shao Huarong, Zhang Xiuhua, Ma Yuxia, Li Gang, Li Hui, Gao Shuzhong, Ling Peixue
Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Post-doctoral Scientific Research Workstation, Shandong Academy of Pharmaceutical Science, Jinan, China.
Ann Jt. 2023 Dec 19;9:10. doi: 10.21037/aoj-23-65. eCollection 2024.
Connexin 43 (Cx43) is the main gap junction (GJ) protein and hemichannel protein in bone tissue. It is involved in the formation of hemichannels and GJs and establishes channels that can communicate directly to exchange substances and signals, affecting the structure and function of osteocytes. CX43 is very important for the normal development of bone tissue and the establishment and balance of bone reconstruction. However, the molecular mechanisms by which CX43 regulates osteoblast function and homeostasis have been less well studied, and this article provides a review of research in this area.
We searched the PubMed, EMBASE, Cochrane Library, and Web of Science databases for studies published up to June 2023 using the keywords Connexin 43/Cx43 and Osteocytes. Screening of literatures according to inclusion and exclusion guidelines and summarized the results.
Osteocytes, osteoblasts, and osteoclasts all express Cx43 and form an overall network through the interaction between GJs. Cx43 is not only involved in the mechanical response of bone tissue but also in the regulation of signal transduction, which could provide new molecular markers and novel targets for the treatment of certain bone diseases.
Cx43 is expressed in osteoblasts, osteoclasts, and osteoclasts and plays an important role in regulating the function, signal transduction, and mechanotransduction of osteocytes. This review offers a new contribution to the literature by summarizing the relationship between Cx43, a key protein of bone tissue, and osteoblasts.
连接蛋白43（Cx43）是骨组织中主要的间隙连接（GJ）蛋白和半通道蛋白。它参与半通道和GJ的形成，并建立可直接进行物质和信号交换的通道，影响骨细胞的结构和功能。CX43对骨组织的正常发育以及骨重建的建立和平衡非常重要。然而，CX43调节成骨细胞功能和内环境稳态的分子机制尚未得到充分研究，本文对该领域的研究进行综述。
我们使用关键词“连接蛋白43/Cx43”和“骨细胞”在PubMed、EMBASE、Cochrane图书馆和Web of Science数据库中检索截至2023年6月发表的研究。根据纳入和排除标准筛选文献并总结结果。
骨细胞、成骨细胞和破骨细胞均表达Cx43，并通过GJ之间的相互作用形成一个整体网络。Cx43不仅参与骨组织的机械反应，还参与信号转导的调节，这可为某些骨疾病的治疗提供新的分子标志物和新靶点。
Cx43在成骨细胞、破骨细胞和骨细胞中表达，在调节骨细胞的功能、信号转导和机械转导中起重要作用。本综述通过总结骨组织关键蛋白Cx43与成骨细胞之间的关系，为该领域文献做出了新贡献。
