Radiology, Mayo Clinic, Rochester, Minnesota, USA
CÚRAM-Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
J Neurointerv Surg. 2021 Nov;13(11):1040-1043. doi: 10.1136/neurintsurg-2020-017073. Epub 2021 Feb 11.
To develop a preclinical thromboembolic occlusion model for studying revascularization strategies.
Clot analog with barium sulfate was injected into the distal aorta in 9 New Zealand white rabbits. The situation of aorta occlusion was compared among fibrin-rich (n=4), red blood cell (RBC)-rich (n=3), and whole blood clot analogs (n=2) using digital subtraction angiography. Arterial geometries, histologic features and circumferential stretch of the distal aorta in rabbits were compared with the common carotid artery in swine and the distal internal carotid artery (ICA) in humans. Aspiration thrombectomy and mechanical thrombectomy using a stent retriever were performed in two rabbits.
The aortic bifurcation was occluded after a single delivery of clot in 4 cases. It was occluded after the second clot injection in the 5 remaining rabbits. Fragmentation of RBC-rich clots occurred during clot injection in 2 cases. The mean diameters of the distal aorta and right common iliac artery in rabbits were 3.7±0.4 and 2.8±0.3 mm, respectively; the mean diameters of human ICA, and first and second segments of the middle cerebral artery (M1, M2) were 3.6±0.4, 3.1±0.4, and 2.4±0.4 mm, respectively. Arterial revascularization was achieved in both rabbits. Geometric, mechanical and histological factors of the distal aorta in rabbit were more close to human distal ICA than swine carotid artery.
Arterial occlusion can be achieved at the aortic bifurcation in rabbits, which is comparable to human ICA bifurcation. This thrombectomy model has the potential to be used for testing of thrombectomy devices.
开发一种用于研究血管再通策略的临床前血栓栓塞闭塞模型。
在 9 只新西兰白兔的远端主动脉内注射硫酸钡血栓类似物。使用数字减影血管造影术比较富含纤维蛋白（n=4）、富含红细胞（RBC）（n=3）和全血血栓类似物（n=2）的主动脉闭塞情况。比较了兔远端主动脉的动脉几何形状、组织学特征和周向拉伸与猪的颈总动脉和人的远端颈内动脉（ICA）。在 2 只兔中进行了抽吸血栓切除术和使用支架取栓器的机械血栓切除术。
在 4 例中，单次注射血栓后即可闭塞主动脉分叉；在其余 5 只兔中，第二次注射血栓后即可闭塞。在 2 例中，在注射 RBC 丰富的血栓时发生了血栓碎片。兔的远端主动脉和右髂总动脉的平均直径分别为 3.7±0.4 和 2.8±0.3mm；人的 ICA、大脑中动脉（M1、M2）第一段和第二段的平均直径分别为 3.6±0.4、3.1±0.4 和 2.4±0.4mm。两只兔均实现了动脉再通。兔远端主动脉的几何、力学和组织学因素与人类远端 ICA 比猪颈动脉更接近。
可以在兔的主动脉分叉处实现动脉闭塞，与人类 ICA 分叉处相当。这种血栓切除术模型具有用于测试血栓切除术装置的潜力。
