Bates C E
Med Hypotheses. 1988 Feb;25(2):103-9. doi: 10.1016/0306-9877(88)90026-6.
British Columbia Coastal Indians possess abnormal patterns of essential fatty acid (EFA) and prostaglandin (PGE) metabolism as racially determined genetic traits, probably a consequence of evolving for tens of thousands of years on a diet extremely rich in EFA's. EFA metabolism abnormalities and unusual epidemiological patterns suggest fundamental pathologies so subtle as to be obscured in other groups, yet readily observable among these Indians. It is hypothesized that eicosapentaenoic acid and prostaglandin El deficiencies predispose Coastal Indians to food allergies which in turn predispose them to autoimmune, inflammatory, and psychiatric disorders.
英属哥伦比亚沿海印第安人具有异常的必需脂肪酸（EFA）和前列腺素（PGE）代谢模式，这是由种族决定的遗传特征，可能是在富含EFA的饮食上进化了数万年的结果。EFA代谢异常和不寻常的流行病学模式表明存在一些基本病理状况，这些状况非常微妙，在其他群体中难以察觉，但在这些印第安人中却很容易观察到。据推测，二十碳五烯酸和前列腺素E1缺乏使沿海印第安人易患食物过敏，而食物过敏反过来又使他们易患自身免疫性、炎症性和精神性疾病。
