Gusman David-Jonathan-Rodrigues, Matheus Henrique-Rinaldi, Alves Breno-Edson-Sendão, de Oliveira Amanda-Munarolo-Piacenza, Britto Amanda-Cristine-Dos Santos, Novaes Vivian-Cristina-Noronha, Nagata Maria-José-Hitomi, Batista Victor-Eduardo-de Souza, de Almeida Juliano-Milanezi
Department of Diagnostic and Surgery - Periodontics Division. São Paulo State University (UNESP), School of Dentistry, Araçatuba.
Department of periodontics, University of Western Sao Paulo (UNOESTE), Presidente Prudente, Sao Paulo, Brazil.
J Clin Exp Dent. 2021 Feb 1;13(2):e190-e200. doi: 10.4317/jced.57451. eCollection 2021 Feb.
Platelet-rich fibrin (PRF) has been referred to as a second-generation platelet concentrate, associated with improvements on the healing of palatal wounds followed by FGG harvesting. The aim of this systematic review and meta-analysis was to assess the complete wound epithelialization and postoperative pain when PRF was used in palatal wounds following free gingival graft (FGG) harvesting.
PubMed (Medline), EMBASE and Scopus were searched by two independent individuals up to and including March 2020 in order to identify controlled and randomized controlled clinical trials on the use of PRF at palatal donor sites of FGG. The outcomes assessed were epithelialization and postoperative pain. The risk of bias of the included studies was evaluated using Cochrane Collaboration's domain-based two-part tool. Random effects meta-analyses were conducted with 95% confidence intervals.
The search strategy identified 555 potentially eligible articles, of which 6 randomized controlled clinical trials were included. In the qualitative analysis, most studies (83.3%) reported lower postoperative pain in treatment groups, while all studies accessing epithelialization demonstrated earlier complete wound closure in groups treated with PRF. The discomfort and complete re-epithelialization were more favorable in groups PRF when compared to control groups (<0.00001).
Within the limits of the present study, it can be concluded that the use of PRF for wound healing of palatal donor sites of FGG may decrease postoperative pain and induce earlier complete wound epithelialization. Wound healing, oral surgery procedures, pain, postoperative.
富血小板纤维蛋白（PRF）被称为第二代血小板浓缩物，与在游离龈瓣移植（FGG）取材后腭部伤口愈合的改善相关。本系统评价和荟萃分析的目的是评估在FGG取材后的腭部伤口使用PRF时的完全伤口上皮化和术后疼痛情况。
由两名独立人员检索截至2020年3月的PubMed（Medline）、EMBASE和Scopus数据库，以识别关于在FGG腭部供区使用PRF的对照和随机对照临床试验。评估的结果为上皮化和术后疼痛。使用Cochrane协作网基于领域的两部分工具评估纳入研究的偏倚风险。进行随机效应荟萃分析并给出95%置信区间。
检索策略共识别出555篇潜在符合条件的文章，其中纳入了6项随机对照临床试验。在定性分析中，大多数研究（83.3%）报告治疗组术后疼痛较低，而所有评估上皮化的研究均表明，使用PRF治疗的组伤口完全闭合更早。与对照组相比，PRF组的不适和完全重新上皮化情况更有利（<0.00001）。
在本研究的局限性范围内，可以得出结论，在FGG腭部供区伤口愈合中使用PRF可能会减轻术后疼痛并促使伤口更早完全上皮化（伤口愈合、口腔外科手术、疼痛、术后）。
