Isler Sila Cagri, Uraz Ahu, Guler Berceste, Ozdemir Yucel, Cula Serpil, Cetiner Deniz
1 Department of Periodontology, Faculty of Dentistry, Gazi University , Ankara, Turkey .
2 Department of Periodontology, Faculty of Dentistry, Dumlupınar University , Kütahya, Turkey .
Photomed Laser Surg. 2018 Nov;36(11):571-580. doi: 10.1089/pho.2018.4492. Epub 2018 Sep 27.
The aim of this study was to compare the effects of laser photobiomodulation (PBM) and topical ozone therapy on the reepithelialization of palatal donor site wounds through clinical assessment and computer-aided image analysis and to assess the patient morbidity following free gingival graft (FGG) surgeries.
Thirty-six patients requiring FGG were randomly allocated into three groups: laser group (n = 12), ozone group (n = 12), and control group (n = 12). Epithelialization was evaluated by applying 3% hydrogen peroxide (HO) to the wound area and also measured by using digital image analysis (ImageJ). Bland-Altman plots were used for assessing agreement between HO and ImageJ measurements. Parameters in relation to patient morbidity were assessed by using visual analog scale (VAS) on the first 3, 7, 14, and 30 days postoperatively.
At day 14, statistically significant smaller wounds were observed with digital image analysis in the ozone group as compared with the control group (p = 0.034). However, intergroup comparison of the remaining wound area evaluated by the clinician using the HO method did not reveal any significant differences (p > 0.05). Nonetheless, according to Bland-Altman analysis, the lower and upper limits showed a moderate agreement between the two measurement methods. The mean VAS sores exhibiting postoperative discomfort was observed to be significantly higher in the control group compared with the laser group (p = 0.002) and ozone group (p < 0.001) at day 7.
Adjunctive ozone therapy could have a significantly beneficial effect on the acceleration of palatal wound healing following FGG procedures. Both PBM and ozone treatment modalities reduced postoperative discomfort as compared with spontaneous healing.
本研究旨在通过临床评估和计算机辅助图像分析，比较激光光生物调节（PBM）和局部臭氧疗法对腭部供区伤口再上皮化的影响，并评估游离龈移植（FGG）手术后患者的发病率。
36例需要进行FGG的患者被随机分为三组：激光组（n = 12）、臭氧组（n = 12）和对照组（n = 12）。通过向伤口区域涂抹3%过氧化氢（HO）来评估上皮化情况，并使用数字图像分析（ImageJ）进行测量。使用Bland-Altman图评估HO和ImageJ测量之间的一致性。在术后第1、3、7、14和30天，使用视觉模拟量表（VAS）评估与患者发病率相关的参数。
在第14天，与对照组相比，臭氧组通过数字图像分析观察到伤口在统计学上明显更小（p = 0.034）。然而，临床医生使用HO方法评估的剩余伤口面积的组间比较未显示出任何显著差异（p > 0.05）。尽管如此，根据Bland-Altman分析，下限和上限显示两种测量方法之间具有中等一致性。在第7天，观察到对照组术后不适的平均VAS疼痛评分明显高于激光组（p = 0.002）和臭氧组（p < 0.001）。
辅助臭氧疗法对FGG手术后腭部伤口愈合的加速可能具有显著的有益效果。与自然愈合相比，PBM和臭氧治疗方式均降低了术后不适。
