The spread of coronavirus (COVID-19) has resulted in a drastic alteration to billions of individuals' emotional, physical, mental, social, and financial status. As of July 21, 2020, there had been 14.35 million confirmed cases of COVID-19, including 0.60 million deaths in 216 countries. The study explores health and wellbeing in universities within the G20 countries (19 member countries and the European Union) during the COVID-19 pandemic. The sample selection of these countries was considered since it serves around 80% of the world's economic output, two-thirds of the global population (including more than half of the world's poor), and 75% of international trade. Specifically, due to this public health concern, schools' nationwide closures are impacting over 60% of the world's student population to promote their quality of life and well-being. This study investigates the G20 policies and procedures within higher education regarding health and well-being measures during the COVID-19 epidemic. The findings reveal that the lockdown, social distancing, and self-isolation requirements are stressful and detrimental for many individuals and have caused students' health and well-being concerns. Several countries within the G20 have taken significant steps to support health and well-being issues for university students; however, numerous countries are far behind in addressing this issue. Hence, government leaders of G20 countries, policymakers, and health providers should promptly take the necessary measures to regulate the outbreak, improve safety measures to decrease disease transmission, and administer those who demand medical attention.