对甲状腺疾病患者及其亲属的抗原刺激淋巴细胞衍生的迁移增强和抑制因子的检测。

Assays for antigen-stimulated lymphocyte-derived migration enhancement and inhibition factors from patients with thyroid diseases and their relatives.

作者信息

Matsui Y, Beall G N, Chopra I J, Solomon D H, Kruger S, Beall M

出版信息

Acta Endocrinol (Copenh). 1977 Dec;86(4):733-41. doi: 10.1530/acta.0.0860733.

DOI:10.1530/acta.0.0860733

Abstract

Cell-mediated immunity to thyroid antigens was studied by means of an assay for antigen-stimulated leukocyte migration inhibition factor (LIF) in 5 groups of subjects: patients with Graves' disease, Hashimoto's thyroiditis, their relatives and normal controls. We also sought evidence for the possibility that the hypothesized migration enhancement factor (MEF) might be produced by lymphocytes from patients with autoimmune disorders. We found little evidence of LIF production and none of MEF production by the leukocytes of patients with autoimmune thyroid diseases upon exposure to thyroid antigens. Similarly, either no or only minimal amounts of LIF were demonstrated in culture supernatants of leukocytes of their immediate relatives.

摘要

通过检测抗原刺激的白细胞迁移抑制因子（LIF），对5组受试者的甲状腺抗原细胞介导免疫进行了研究，这5组受试者包括格雷夫斯病患者、桥本甲状腺炎患者、他们的亲属以及正常对照者。我们还探寻证据，以证明自身免疫性疾病患者的淋巴细胞可能产生假定的迁移增强因子（MEF）。我们发现，自身免疫性甲状腺疾病患者的白细胞在接触甲状腺抗原后，几乎没有产生LIF的证据，也没有产生MEF的证据。同样，他们直系亲属白细胞培养上清液中要么没有检测到LIF，要么只检测到极少量的LIF。