National Supercomputer Research Center of Advanced Materials, Advanced Materials Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
Luminescence. 2021 Jun;36(4):951-957. doi: 10.1002/bio.4021. Epub 2021 Feb 25.
A novel copper ion sensing periodic mesoporous organosilica (SCN-PMO) was obtained by incorporating a Schiff base-based fluorescent receptor into the pore walls of mesoporous silica, which exhibited a well ordered mesoporous structure and excellent optical properties demonstrated by various characterization results. SCN-PMO possessed high selectivity and sensitivity towards Cu based on its specific fluorescence response. The detection limit of SCN-PMO could be as low as 6.7 × 10 M. Due to protection of the silica network, SCN chromophores in PMOs exhibited higher photostability and the resulting material possessed great repeatability. Additionally, the fluorescence changes of SCN-PMO towards copper ions in vivo (zebrafish) showed that SCN-PMO has potential application as a nanoprobe in biological fields.
一种新型的铜离子感应的周期性介孔有机硅（SCN-PMO）是通过将基于席夫碱的荧光受体掺入介孔硅的孔壁中而获得的，该材料表现出良好的有序介孔结构和优异的光学性能，这是通过各种特征化结果证明的。SCN-PMO 基于其特定的荧光响应，对基于铜的物质具有高选择性和灵敏度。SCN-PMO 的检测限可低至 6.7×10 M。由于硅网络的保护，PMO 中的 SCN 生色团表现出更高的光稳定性，并且所得材料具有很好的重复性。此外，SCN-PMO 对活体（斑马鱼）中铜离子的荧光变化表明，SCN-PMO 具有作为生物领域纳米探针的潜在应用。
