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COVID-19 疫情和封锁期间的中毒事件:法国中毒控制中心报告的暴露情况回顾性分析。

Poisoning during the COVID-19 outbreak and lockdown: retrospective analysis of exposures reported to French poison control centres.

机构信息

Centre antipoison et de Toxicovigilance Grand Ouest, CHU Angers, Angers Cedex 9, France.

Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Maisons-Alfort Cedex, France.

出版信息

Clin Toxicol (Phila). 2021 Sep;59(9):832-839. doi: 10.1080/15563650.2021.1874402. Epub 2021 Feb 12.

Abstract

INTRODUCTION

The aim was to assess the impact of the COVID-19 pandemic on French Poison Control Centre (PCC) call characteristics.

METHODS

Reported cases of xenobiotic exposures from 1 March to 30 April in 2018, 2019, and 2020 were extracted from the French National Database of Poisonings. The collected data included call, patient, and exposure characteristics for both general calls and for calls involving sentinel xenobiotic categories related to the COVID-19 pandemic. The 2020 exposures were compared to 2018-2019 exposures by using simple logistic models in order to provide effect size with odds ratios.

RESULTS

From March to April 2020, 32,182 exposures were reported to French PCCs with an overall increase of 5.6% compared to exposures in the same time frame in 2018-2019. A similar increase in calls was observed in non-epidemic and epidemic COVID-19 areas with an increase in calls from the public (+13.6%) while calls from health-professionals decreased (-7.5%). Despite the increase in exposures, the incidence of symptomatic exposures remained stable (-0.4%) with a decrease in severity (moderate/severe -17.2%). A significant increase in exposures to home cleaning products containing biocides, essential oils, and alcohol-based hand sanitizers (odds ratio >1.3,  < .0001) was observed.

DISCUSSION AND CONCLUSION

The COVID-19 pandemic altered calls to French PCCs with a small increase in calls during the study period and changes in the pattern of exposure. These changes possibly reflected the indirect consequences of the COVID-19 pandemic i.e., limited access to primary care, fear of contracting COVID-19 and anxiety related to home isolation.

摘要

简介

本研究旨在评估 COVID-19 大流行对法国中毒控制中心(PCC)来电特征的影响。

方法

从法国国家中毒数据库中提取了 2018 年、2019 年和 2020 年 3 月 1 日至 4 月 30 日期间报告的异源生物暴露病例。收集的数据包括一般来电和与 COVID-19 大流行相关的哨点异源生物类别来电的来电、患者和暴露特征。使用简单逻辑回归模型比较 2020 年暴露与 2018-2019 年暴露,以提供比值比的效应大小。

结果

2020 年 3 月至 4 月,法国 PCC 共报告 32182 例暴露,与 2018-2019 年同期相比总体增长 5.6%。在非流行和流行的 COVID-19 地区,来电数量也出现了类似的增长,公众来电增加(+13.6%),而卫生专业人员来电减少(-7.5%)。尽管暴露量增加,但症状性暴露的发生率保持稳定(-0.4%),严重程度降低(中度/重度-17.2%)。观察到家用清洁产品中含有杀生物剂、精油和酒精基洗手液的暴露显著增加(比值比>1.3,<0.0001)。

讨论与结论

COVID-19 大流行改变了法国 PCC 的来电情况,研究期间来电略有增加,暴露模式发生变化。这些变化可能反映了 COVID-19 大流行的间接后果,即初级保健服务受限、对感染 COVID-19 的恐惧以及与家庭隔离相关的焦虑。

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