Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, Hefei 230032, China.
Food Funct. 2021 Mar 7;12(5):1856-1881. doi: 10.1039/d0fo02342f. Epub 2021 Feb 12.
Phellinus Quél is one of the largest genera of Hymenochaetaceae, which is comprised of about 220 species. Most Phellinus macro-fungi are perennial lignicolous mushrooms, which are widely distributed on Earth. Some Phellinus fungi are historically recorded as traditional medicines used to treat various diseases in eastern Asian countries, especially China, Japan and Korean. Previous phytochemical studies have revealed that Phellinus fungi produce diverse secondary metabolites, which mainly contain polysaccharides, flavones, coumarins, terpenes, steroids, and styrylpyranones. Pharmacological documents have demonstrated that Phellinus mushrooms and their compounds have a variety of bioactivities, such as anti-tumor, immunomodulation, anti-oxidative and anti-inflammation, anti-diabetes, neuro-protection, and anti-viral effects. This review surveys the literature reporting the isolation, characterization, and bioactivities of secondary metabolites from the fungi of the genus Phellinus, focusing on studies published in the literature up to April 2020. Herein, a total of more than 300 compounds from 13 Phellinus species and their isolation, characterization, chemistry, pharmacological activities, and relevant molecular mechanisms are comprehensively summarized.
木层孔菌属是木层孔菌科中最大的属之一，包含约 220 种。大多数木层孔菌是多年生木质腐生菌，广泛分布于地球。一些木层孔菌真菌被历史记录为传统药物，用于治疗东亚国家（特别是中国、日本和韩国）的各种疾病。先前的植物化学研究表明，木层孔菌产生多种次生代谢产物，主要包含多糖、黄酮类、香豆素、萜类、甾体和苯乙烯基吡喃酮。药理学文献表明，木层孔菌蘑菇及其化合物具有多种生物活性，如抗肿瘤、免疫调节、抗氧化和抗炎、抗糖尿病、神经保护和抗病毒作用。本综述调查了文献中报道的从木层孔菌属真菌中分离、鉴定和生物活性的次生代谢产物，重点关注截至 2020 年 4 月发表的文献。本文共综述了来自 13 种木层孔菌及其分离、鉴定、化学、药理活性和相关分子机制的 300 多种化合物。
