LIM23, Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Geroscience. 2021 Feb;43(1):225-237. doi: 10.1007/s11357-021-00329-x. Epub 2021 Feb 12.
The choroid plexus (CP) is an important structure for the brain. Besides its major role in the production of cerebrospinal fluid (CSF), it conveys signals originating from the brain, and from the circulatory system, shaping brain function in health and in pathology. Previous studies in rodents have revealed altered transcriptome both during aging and in various diseases of the central nervous system, including Alzheimer's disease. In the present study, a high-throughput sequencing of the CP transcriptome was performed in postmortem samples of clinically healthy individuals aged 50's through 80's. The data shows an age-related profile, with the main changes occurring in the transition from the 50's to the 60's, stabilizing thereafter. Specifically, neuronal and membrane functions distinguish the transcriptome between the 50's and the 60's, while neuronal and axon development and extracellular structure organization differentiate the 50's from the 70's. These findings suggest that changes in the CP transcriptome occur early in the aging process. Future studies will unravel whether these relate with processes occurring in late- onset brain diseases.
脉络丛（CP）是大脑的重要结构。除了在产生脑脊液（CSF）方面的主要作用外，它还传递来自大脑和循环系统的信号，从而塑造健康和病理状态下的大脑功能。先前在啮齿动物中的研究揭示了在衰老过程中和中枢神经系统的各种疾病（包括阿尔茨海默病）中，转录组发生了改变。在本研究中，对 50 多岁至 80 多岁临床健康个体的死后 CP 转录组进行了高通量测序。数据显示出与年龄相关的特征，主要变化发生在从 50 多岁到 60 多岁的过渡期间，此后趋于稳定。具体而言，神经元和膜功能将 50 多岁和 60 多岁之间的转录组区分开来，而神经元和轴突发育以及细胞外结构组织的区分则将 50 多岁与 70 多岁区分开来。这些发现表明 CP 转录组的变化发生在衰老过程的早期。未来的研究将阐明这些变化是否与晚期发病的脑部疾病中发生的过程有关。
