Hellerstein S, Duggan E, Savage B
Section of Pediatric Nephrology, Children's Mercy Hospital, Kansas City, MO 64108.
Pediatr Infect Dis J. 1988 Mar;7(3):180-5. doi: 10.1097/00006454-198803000-00010.
A report that elevated urinary lactic acid dehydrogenase (LDH) isoenzyme 5 activity is a reliable tool for separating patients with upper from those with lower urinary tract infections (UTIs) led us to study urinary LDH enzyme activity in girls having bladder washout studies to localize the site of infection. Urinary LDH isoenzyme 5 activity in 64 instances of lower UTI was 16.1 +/- 3.3%, a value not significantly different than that of 18.2 +/- 12.6% found in 26 instances of upper tract infection (t = 0.8726, P = 0.1928). The data show that LDH isoenzyme 5 activity is of no value for localization of the site of a UTI. The data of these studies also showed that urinary LDH enzyme activity clearly separates girls with UTIs from those without infections, but it is unlikely that this finding will be of value in diagnosis or management.
一份报告称，尿乳酸脱氢酶（LDH）同工酶5活性升高是区分上尿路感染和下尿路感染患者的可靠工具，这促使我们对接受膀胱冲洗研究以确定感染部位的女孩的尿LDH酶活性进行研究。64例下尿路感染患者的尿LDH同工酶5活性为16.1±3.3%，与26例上尿路感染患者中发现的18.2±12.6%的值无显著差异（t = 0.8726，P = 0.1928）。数据表明，LDH同工酶5活性对尿路感染部位的定位没有价值。这些研究数据还表明，尿LDH酶活性可明确区分患有尿路感染的女孩和未感染的女孩，但这一发现不太可能在诊断或治疗中具有价值。
