From the Division of Diagnostic Imaging, Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
Clin Nucl Med. 2021 Jul 1;46(7):592-594. doi: 10.1097/RLU.0000000000003522.
Patient was a 73-year-old woman with metastatic renal cell carcinoma. Bone scan showed multifocal bone metastases. The patient received cabozantinib treatment for more than 1 year. On the follow-up bone scan, the previously biopsy-proven left pelvic bone lesion has improved, whereas the right maxillary lesion showed increased extent and intensity of abnormal radiotracer uptake. Given the different change pattern of these lesions, the right maxillary lesion was further evaluated. Biopsy results confirmed devitalized bone with bacterial colonies overgrowth and without tumor cell, suggestive of medication-related osteonecrosis.
患者为 73 岁女性，患有转移性肾细胞癌。骨扫描显示多处骨转移。该患者接受卡博替尼治疗超过 1 年。在后续的骨扫描中，之前经活检证实的左侧骨盆骨病变有所改善，而右侧上颌骨病变的范围和异常放射性示踪剂摄取的强度增加。鉴于这些病变的变化模式不同，对右侧上颌骨病变进行了进一步评估。活检结果证实骨失活，有细菌菌落过度生长，无肿瘤细胞，提示与药物相关的骨坏死。
