Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-7288, USA; email:
Annu Rev Immunol. 2021 Apr 26;39:511-536. doi: 10.1146/annurev-immunol-101819-074237. Epub 2021 Feb 12.
The surfaces of all living organisms and most secreted proteins share a common feature: They are glycosylated. As the outermost-facing molecules, glycans participate in nearly all immunological processes, including driving host-pathogen interactions, immunological recognition and activation, and differentiation between self and nonself through a complex array of pathways and mechanisms. These fundamental immunologic roles are further cast into sharp relief in inflammatory, autoimmune, and cancer disease states in which immune regulation goes awry. Here, we review the broad impact of glycans on the immune system and discuss the changes and clinical opportunities associated with the onset of immunologic disease.
它们是糖基化的。作为最外层的分子，聚糖参与了几乎所有的免疫过程，包括通过一系列复杂的途径和机制驱动宿主-病原体相互作用、免疫识别和激活，以及区分自我和非自我。在免疫调节失常的炎症、自身免疫和癌症疾病状态下，这些基本的免疫作用更加明显。在这里，我们综述了聚糖对免疫系统的广泛影响，并讨论了与免疫疾病发生相关的变化和临床机会。
