State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
Pharmacol Res. 2021 Mar;165:105483. doi: 10.1016/j.phrs.2021.105483. Epub 2021 Feb 10.
Isobavachalcone (IBC), a naturally occurring chalcone, is mainly isolated from the seeds of Psoralea corylifolia Linn. IBC demonstrates multiple pharmacological activities, including anti-cancer, anti-microbial, anti-inflammatory, antioxidative, neuroprotective, and among others. Several potential targets of IBC, such as AKT, dihydroorotate dehydrogenase (DHODH), have been identified. The pharmacokinetic profiles of IBC have been reported as well. In this review, the pharmacological activities, the underlying mechanisms, the potential targets, and the pharmacokinetic profiles of IBC were summarized. IBC might be a promising lead compound for drug discovery.
异甘草查尔酮（IBC）是一种天然查尔酮，主要从补骨脂种子中分离得到。IBC 具有多种药理活性，包括抗癌、抗菌、抗炎、抗氧化、神经保护等。已经鉴定出 IBC 的几个潜在靶点，如 AKT、二氢乳清酸脱氢酶（DHODH）等。IBC 的药代动力学特征也有报道。本文总结了 IBC 的药理作用、作用机制、潜在靶点和药代动力学特征。IBC 可能是药物发现有前途的先导化合物。
