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Proc Natl Acad Sci U S A. 1988 Apr;85(8):2830-3. doi: 10.1073/pnas.85.8.2830.
2
Learning in Aplysia: looking at synaptic plasticity from both sides.海兔的学习：从两个角度审视突触可塑性。
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Feeding behavior of Aplysia: a model system for comparing cellular mechanisms of classical and operant conditioning.海兔的进食行为：一个用于比较经典条件作用和操作性条件作用细胞机制的模型系统。
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The neurobiology of learning and memory.学习与记忆的神经生物学
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Differential classical conditioning of a defensive withdrawal reflex in Aplysia californica.加州海兔防御性退缩反射的差异经典条件作用
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一种没有突触可塑性的经典条件作用的合理神经回路。

A plausible neural circuit for classical conditioning without synaptic plasticity.

作者信息

Tesauro G

机构信息

Center for Complex Systems Research, University of Illinois at Urbana-Champaign 61820.

出版信息

Proc Natl Acad Sci U S A. 1988 Apr;85(8):2830-3. doi: 10.1073/pnas.85.8.2830.

DOI:10.1073/pnas.85.8.2830
PMID:3357894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC280093/
Abstract

The cellular bases of learning are currently under active investigation by both experimental and theoretical means. In this paper, a simple neuronal wiring diagram is proposed that can reproduce both simple and higher-order behavioral paradigms seen in invertebrate classical conditioning experiments. Learning in this model does not take place by modification of synaptic strength values. Instead, the model uses a layer of interneurons with modifiable thresholds for spike initiation, as suggested by the plasticity mechanisms thought to operate in Hermissenda [Alkon, D. L. (1983) Sci. Am. 249, 70-84]. The model therefore has an advantage in plausibility compared with more standard models using Hebb synapses or their functional equivalents, which have not yet been demonstrated in any invertebrate organism.

摘要

目前，人们正在通过实验和理论方法积极研究学习的细胞基础。本文提出了一种简单的神经元接线图，它可以重现无脊椎动物经典条件反射实验中出现的简单和高阶行为模式。该模型中的学习并非通过修改突触强度值来实现。相反，正如被认为在海兔中起作用的可塑性机制所表明的那样[阿尔孔，D. L.（1983年）《科学美国人》249，70 - 84页]，该模型使用了一层具有可修改动作电位起始阈值的中间神经元。因此，与使用赫布突触或其功能等效物的更标准模型相比，该模型在合理性方面具有优势，而这些标准模型尚未在任何无脊椎动物中得到证实。