血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性与肺癌的关联：一项更新的系统评价和荟萃分析。

Associations between I/D polymorphism in the ACE gene and lung cancer: an updated systematic review and a meta-analysis.

作者信息

Chen Junjian, Sun Mao, Zhou Min, Lu Renfu

机构信息

Department of Cardiothoracic Surgery, Chongqing Emergency Medical Center, Chongqing University Center Hospital, School of Medicine, Chongqing University, No.1 Healthy Road, Yuzhong District, Chongqing, 400014, China.

出版信息

BMC Cancer. 2021 Feb 12;21(1):158. doi: 10.1186/s12885-021-07825-5.

DOI:10.1186/s12885-021-07825-5

PMID:33579229

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7881549/

Abstract

BACKGROUND

We evaluated the association between the I/D polymorphism in the ACE gene and lung cancer risk by performing a meta-analysis.

METHODS

The heterogeneity in the study was tested using the Cochran χ-based Q statistic test and I test, and then the random ratio or fixed effect was utilized to merge the odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the strength of the association between ACE polymorphisms and susceptibility to lung cancer. Sensitivity analysis was also performed. Using funnel plot and Begg's rank test, we investigated the publication bias. All statistical analyses were performed using Stata 12.0 and RevMan 5.3.

RESULTS

A total of 4307 participants (2181 patients; 2126 controls) were included in the 12 case-control studies. No significant association was found between the ACE I/D polymorphism and lung cancer risk (II vs. ID + DD: OR = 1.22, 95% CI = 0.89-1.68; II + ID vs. DD: OR = 1.21, 95% CI = 0.90-1.63; I vs. D: OR = 1.15, 95% CI = 0.95-1.39). In the subgroup analysis by ethnicity, no significant association between the ACE I/D polymorphism and lung cancer risk was found among Asian and Caucasian populations for the comparisons of II vs. ID + DD, II + ID vs. DD, and I vs. D genetic models.

CONCLUSION

The ACE I/D polymorphism is not associated with the risk of lung cancer.

摘要

背景

我们通过进行一项荟萃分析来评估血管紧张素转换酶（ACE）基因的I/D多态性与肺癌风险之间的关联。

方法

使用基于Cochran χ的Q统计检验和I检验来检验研究中的异质性，然后采用随机效应模型或固定效应模型合并比值比（OR）和95%置信区间（CI），以估计ACE基因多态性与肺癌易感性之间关联的强度。还进行了敏感性分析。使用漏斗图和Begg秩检验来研究发表偏倚。所有统计分析均使用Stata 12.0和RevMan 5.3进行。

结果

12项病例对照研究共纳入4307名参与者（2181例患者；2126例对照）。未发现ACE基因的I/D多态性与肺癌风险之间存在显著关联（II与ID + DD相比：OR = 1.22，95% CI = 0.89 - 1.68；II + ID与DD相比：OR = 1.21，95% CI = 0.90 - 1.63；I与D相比：OR = 1.15，95% CI = 0.95 - 1.39）。在按种族进行的亚组分析中，在亚洲和白种人群中，对于II与ID + DD、II + ID与DD以及I与D遗传模型的比较，未发现ACE基因的I/D多态性与肺癌风险之间存在显著关联。