血管紧张素转换酶基因多态性与癌症易感性的关联：一项荟萃分析。
Association between angiotensin I-converting enzyme gene polymorphism and susceptibility to cancer: a meta analysis.
作者信息
Zhang Kan, Cheng Dan, Yi Lingling, Shi Huimin, Zhen Guohua
机构信息
Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China ; Key Laboratory of Respiratory Diseases, National Health and Family Planning Commission of the People's Republic of China Wuhan, China.
出版信息
Int J Clin Exp Pathol. 2014 Aug 15;7(9):6291-300. eCollection 2014.
BACKGROUND
Angiotensin I-converting enzyme (ACE) gene plays an important role in the pathogenesis of cancers. The association between ACE insertion/deletion (I/D) polymorphism and the risk of various cancers has been studied. However, the results of these studies remain conflicting. Therefore, we performed a meta-analysis to evaluate the association between ACE I/D polymorphism and the risk of cancers.
METHODS
PubMed, Embase, ScienceDirect, Springer, CNKI, Wanfang, Weipu, CBM databases and Google Scholar were searched for case-control studies on ACE I/D polymorphism and the risk of cancers, published up to Dec 31, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association between ACE I/D polymorphism and cancer risk.
RESULTS
Thirty-five published studies with 5007 cases and 8173 controls were included. Overall, there were no significant association between ACE I/D polymorphism and the risk of cancers (II vs. ID+DD OR = 1.05, 95% CI = 0.89-1.23, I vs. D OR = 1.00, 95% CI = 0.89-1.13). However, when stratified by ethnicity, we found a significant association between this polymorphism and cancer risk in Caucasians (II vs. ID+DD: OR = 1.43, 95% CI = 1.02-2.00, I vs. D: OR = 1.23, 95% CI 1.01-1.49).
CONCLUSION
ACE I/D polymorphism is associated with the cancer risk in Caucasians.
背景
血管紧张素I转换酶（ACE）基因在癌症发病机制中起重要作用。已对ACE插入/缺失（I/D）多态性与各种癌症风险之间的关联进行了研究。然而，这些研究结果仍存在冲突。因此，我们进行了一项荟萃分析，以评估ACE I/D多态性与癌症风险之间的关联。
方法
检索了PubMed、Embase、ScienceDirect、Springer、中国知网、万方、维普、中国生物医学文献数据库以及谷歌学术，查找截至2013年12月31日发表的关于ACE I/D多态性与癌症风险的病例对照研究。采用比值比（OR）及95%置信区间（CI）评估ACE I/D多态性与癌症风险之间关联的强度。
结果
纳入了35项已发表研究，共5007例病例和8173例对照。总体而言，ACE I/D多态性与癌症风险之间无显著关联（II vs. ID+DD：OR = 1.05，95% CI = 0.89 - 1.23；I vs. D：OR = 1.00，95% CI = 0.89 - 1.13）。然而，按种族分层时，我们发现该多态性与白种人的癌症风险之间存在显著关联（II vs. ID+DD：OR = 1.43，95% CI = 1.02 - 2.00；I vs. D：OR = 1.23，95% CI 1.01 - 1.49）。
结论
ACE I/D多态性与白种人的癌症风险相关。
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