Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Trends Biochem Sci. 2021 Jul;46(7):535-549. doi: 10.1016/j.tibs.2021.01.002. Epub 2021 Feb 10.
Liquid-liquid phase separation (LLPS) has emerged in recent years as an important physicochemical process for organizing diverse processes within cells via the formation of membraneless organelles termed biomolecular condensates. Emerging evidence now suggests that the formation and regulation of biomolecular condensates are also intricately linked to cancer formation and progression. We review the most recent literature linking the existence and/or dissolution of biomolecular condensates to different hallmarks of cancer formation and progression. We then discuss the opportunities that this condensate perspective provides for cancer research and the development of novel therapeutic approaches, including the perturbation of condensates by small-molecule inhibitors.
近年来，液-液相分离（LLPS）作为一种重要的物理化学过程，通过形成无膜细胞器（称为生物分子凝聚物）来组织细胞内的各种过程。新出现的证据表明，生物分子凝聚物的形成和调节也与癌症的形成和发展密切相关。我们回顾了最近将生物分子凝聚物的存在和/或溶解与癌症形成和发展的不同特征联系起来的文献。然后，我们讨论了这种凝聚物视角为癌症研究和新治疗方法的发展提供的机会，包括通过小分子抑制剂干扰凝聚物。
