Division of Otolaryngology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Units of Neurology and Neurophysiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
J Vestib Res. 2021;31(4):297-301. doi: 10.3233/VES-200788.
Ménière's disease (MD) is an inner ear disorder characterized by a burden of symptoms and comorbidities, including migraine. In both disorders, ionic dysregulation may play a role as a predisposing factor. In recent years. aquaporins have been widely investigated, but the results are far from conclusive. We recently studied the genetics of ionic transporters and the hormone endogenous ouabain as predisposing factors for development of MD. In particular, we found two genetic polymorphisms associated with MD: 1) rs3746951, a missense variant (Gly180Ser) in the salt-inducible kinase-1 (SIK1) gene encoding a Na+, K+ ATPase; 2) rs487119, an intronic variant of gene SLC8A1 coding for a Na+, Ca++ exchanger (NCX-1). Ionic concentration in the brain also plays a role in the pathophysiology of migraine. In this brief review we summarize what has been published on MD and migraine.
梅尼埃病（MD）是一种内耳疾病，其特征是症状和合并症负担沉重，包括偏头痛。在这两种疾病中，离子失调可能作为一个易感因素发挥作用。近年来，水通道蛋白已被广泛研究，但结果远未得出结论。我们最近研究了离子转运体和内源性哇巴因激素作为 MD 发病的易感因素的遗传学。特别是，我们发现了两个与 MD 相关的遗传多态性：1）rs3746951，编码 Na+，K+ATP 酶的盐诱导激酶-1（SIK1）基因中的错义变异（Gly180Ser）；2）rs487119，编码 Na+，Ca++交换器（NCX-1）的 SLC8A1 基因的内含子变异。大脑中的离子浓度也在偏头痛的病理生理学中发挥作用。在这篇简短的综述中，我们总结了已发表的关于 MD 和偏头痛的文献。
