Department of Advanced Informatics for Genetic Disease, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Department of Urology, Graduate School of Medicine, Juntendo University, 3-1-3 bunkyo-ku, Hongo, Tokyo, 113-8421, Japan.
Sci Rep. 2021 Feb 12;11(1):3769. doi: 10.1038/s41598-021-83308-8.
Mosaic loss of chromosome Y (mLOY) in leukocytes has attracted much attention as an emerging biomarker of aging and aging-related diseases. We evaluated the usefulness of saliva for mLOY analysis and showed that saliva-derived mLOY is significantly associated with aging and increased physical activity, but not with smoking. While these data support the robust association between saliva-derived mLOY and aging, caution is required when comparing data from saliva-derived and blood-derived mLOY.
染色体 Y 镶嵌缺失（mLOY）在白细胞中的出现引起了人们对衰老和与衰老相关疾病的新兴生物标志物的关注。我们评估了唾液用于 mLOY 分析的有用性，并表明唾液源性 mLOY 与衰老和体力活动增加显著相关，但与吸烟无关。虽然这些数据支持唾液源性 mLOY 与衰老之间的强关联，但在比较唾液源性和血液源性 mLOY 数据时需要谨慎。
