Faculty of Medicine, Saint Joseph University of Beirut, Beirut, Lebanon.
Center Jacques Loiselet for Medical Genetics and Genomics (CGGM), Faculty of Medicine, Saint Joseph University of Beirut, Beirut, Lebanon.
Biogerontology. 2024 Nov;25(6):943-955. doi: 10.1007/s10522-024-10133-7. Epub 2024 Sep 2.
The Y chromosome has long been considered to be a "genetic wasteland" harboring only few genes essentially involved in male sex development and spermatogenesis. However, the discovery of mosaic loss of the Y chromosome (mLOY) in older men has led to revisiting of the potential impact of the Y chromosome on health and the pathophysiological processes of multiple diseases such as cancer, Alzheimer's disease and cardiovascular disease. Hence, developing more sensitive techniques for the detection of mLOY has become an emergent concern. In this article, we present a comprehensive review of the literature regarding mLOY. Additionally, we discuss the emerging discoveries concerning mLOY as well as the underlying mechanisms promoting disease in men of advanced age.
Y 染色体长期以来一直被认为是一个“基因荒地”，只包含少数对男性性发育和精子发生至关重要的基因。然而，在老年男性中发现 Y 染色体镶嵌性缺失（mLOY）后，人们重新审视了 Y 染色体对健康以及多种疾病（如癌症、阿尔茨海默病和心血管疾病）的病理生理过程的潜在影响。因此，开发更敏感的 mLOY 检测技术已成为当务之急。本文对 mLOY 的相关文献进行了全面回顾。此外，我们还讨论了新兴的关于 mLOY 的发现以及促进老年男性患病的潜在机制。
