Laboratori de Medicina Computacional, Unitat de Bioestadistica, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
Department of Biochemistry and Physiology, Universitat de Barcelona, Barcelona, Spain.
Bioinformatics. 2020 May 1;36(10):3271-3272. doi: 10.1093/bioinformatics/btaa117.
G protein-coupled receptors (GPCRs) can form homo-, heterodimers and larger order oligomers that exert different functions than monomers. The pharmacological potential of such complexes is hampered by the limited information available on the type of complex formed and its quaternary structure. Several GPCR structures in the Protein Data Bank display crystallographic interfaces potentially compatible with physiological interactions.
Here, we present DIMERBOW, a database and web application aimed to visually browse the complete repertoire of potential GPCR dimers present in solved structures. The tool is suited to help finding the best possible structural template to model GPCR homomers.
DIMERBOW is available at http://lmc.uab.es/dimerbow/.
Supplementary data are available at Bioinformatics online.
G 蛋白偶联受体（GPCRs）可以形成同型、异型二聚体和更大阶的寡聚体，其发挥的功能与单体不同。由于对所形成的复合物的类型及其四级结构的了解有限，这种复合物的药理学潜力受到阻碍。蛋白质数据库中的几种 GPCR 结构显示出晶体学界面，这些界面可能与生理相互作用兼容。
在这里，我们展示了 DIMERBOW，这是一个数据库和网络应用程序，旨在直观地浏览已解决结构中存在的潜在 GPCR 二聚体的完整库。该工具适合于帮助找到最佳的结构模板来模拟 GPCR 同型二聚体。
DIMERBOW 可在 http://lmc.uab.es/dimerbow/ 上获得。
补充数据可在生物信息学在线获得。
