在小鼠退化视网膜中，移植的下鼻甲来源干细胞在体内分化为视杆光感受器的光镜证据。
Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse.
作者信息
Park Yong Soo, Kim Yeonji, Kim Sung Won, Kim In-Beom
机构信息
Department of Anatomy, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, South Korea.
Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, South Korea.
出版信息
Appl Microsc. 2020 Jun 3;50(1):11. doi: 10.1186/s42649-020-00031-w.
The human turbinate-derived mesenchymal stem cells (hTMSCs), which were DiI-labeled and transplanted into the subretinal space in degenerating mouse retina, were observed in retinal vertical sections processed for rhodopsin (a marker for rod photoreceptor) by confocal microscope with differential interference contrast (DIC) filters. The images clearly demonstrated that DiI-labeled hTMSCs have rhodopsin-immunoreactive appendages, indicating differentiation of transplanted hTMSC into rod photoreceptor. Conclusively, the finding suggests therapeutic potential of hTMSCs in retinal degeneration.
将经DiI标记的人鼻甲来源间充质干细胞（hTMSCs）移植到退化小鼠视网膜的视网膜下间隙，在使用微分干涉差（DIC）滤光片的共聚焦显微镜下，对经视紫红质（视杆光感受器的标志物）处理的视网膜垂直切片进行观察。图像清楚地表明，经DiI标记的hTMSCs具有视紫红质免疫反应性附属物，表明移植的hTMSC分化为视杆光感受器。总之，这一发现提示了hTMSCs在视网膜变性中的治疗潜力。
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