Rattner Amir, Nathans Jeremy
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Nat Rev Neurosci. 2006 Nov;7(11):860-72. doi: 10.1038/nrn2007. Epub 2006 Oct 11.
The central retina mediates high acuity vision, and its progressive dysfunction due to macular degeneration is the leading cause of visual disability among adults in industrialized societies. Here, we summarize recent progress in understanding the pathophysiology of macular degeneration and the implications of this new knowledge for treatment and prevention. The past decade has witnessed remarkable advances in this field, including the development of new, non-invasive retinal imaging technologies, the development of animal models for macular disease, and the isolation of many of the genes responsible for both early- and late-onset macular diseases. These advances have set the stage for the development of effective mechanism-based therapies.
视网膜中央区域介导高敏锐度视觉，而黄斑变性导致的其进行性功能障碍是工业化社会中成年人视力残疾的主要原因。在此，我们总结了在理解黄斑变性病理生理学方面的最新进展以及这些新知识对治疗和预防的意义。过去十年见证了该领域的显著进展，包括新型非侵入性视网膜成像技术的发展、黄斑疾病动物模型的开发以及许多早发性和迟发性黄斑疾病相关基因的分离。这些进展为基于机制的有效疗法的开发奠定了基础。
