Keenan Research Centre for Biomedical Science, St. Michael's Hospital - Unity Health Toronto, University of Toronto, Toronto, Ontario, Canada.
Department of Surgery, Division of Orthopaedic Surgery, University of Western Ontario, London, Ontario, Canada.
J Orthop Res. 2021 Jul;39(7):1359-1367. doi: 10.1002/jor.25003. Epub 2021 Feb 24.
Fracture healing is a complex process requiring mechanical stability, an osteoconductive matrix, and osteoinductive and osteogenic biology. This intricate process is easily disrupted by various patient factors such as chronic disease and lifestyle. As the medical complexity and age of patients with fractures continue to increase, the importance of developing relevant experimental models is becoming paramount in preclinical research. The objective of this review is to describe the most common small animal models of systemically impaired fracture healing used in the orthopedic literature including osteoporosis, diabetes mellitus, smoking, alcohol use, obesity, and ageing. This review will provide orthopedic researchers with a summary of current models of systemically impaired fracture healing used in small animals and present an overview of the methods of induction for each condition.
骨折愈合是一个复杂的过程，需要机械稳定性、骨传导基质以及成骨和诱导生物学。这个复杂的过程很容易被各种患者因素破坏，如慢性病和生活方式。随着骨折患者的医疗复杂性和年龄不断增加，开发相关实验模型在临床前研究中变得至关重要。本综述的目的是描述骨科文献中常用的系统受损骨折愈合的常见小动物模型，包括骨质疏松症、糖尿病、吸烟、饮酒、肥胖和衰老。本综述将为骨科研究人员提供一个总结目前用于小动物的系统受损骨折愈合模型，并概述每种情况下的诱导方法。
