Core Technology Laboratories, Asahi Quality and Innovations, Ltd., Ibaraki, Japan.
Tokyo Skytree Medical Clinic, Tokyo, Japan.
Biosci Biotechnol Biochem. 2021 Mar 24;85(4):948-956. doi: 10.1093/bbb/zbaa117.
Lactononadecapeptide (LNDP; NIPPLTQTPVVVPPFLQPE) is a memory-improving peptide. The current study aimed to determine the effects of a single dose of tablets containing LNDP on cognitive function in healthy Japanese men aged 30-59 years. A randomized, double-blind, cross-over, placebo-controlled trial was conducted in participants randomly assigned to receive LNDP or placebo tablets. The Uchida-Kraepelin test was used to induce cognitive load in participants as a model of work load. Cognitive function was evaluated using the Japanese version of the CNS Vital Signs. Composite memory and verbal memory were significantly higher following consumption of LNDP than placebo tablets. Carryover effects were observed in attention and concentration domains so that period 1 data was analyzed. LNDP consumption led to higher processing speed, executive function, and cognitive flexibility than placebo. Thus, supplementation with a single dose of LNDP tablets may improve cognitive functions including memory, attention, concentration, and information processing in daily life.
乳酮宁肽（LNDP；NIPPLTQTPVVVPPFLQPE）是一种改善记忆的肽。本研究旨在确定单次服用含有 LNDP 的片剂对 30-59 岁健康日本男性认知功能的影响。将参与者随机分配接受 LNDP 或安慰剂片剂，进行了一项随机、双盲、交叉、安慰剂对照试验。Uchida-Kraepelin 测试被用于诱导认知负荷，作为工作负荷模型。使用 CNS 生命体征的日本版评估认知功能。复合记忆和言语记忆在服用 LNDP 后明显高于安慰剂片剂。因此，在注意力和集中力领域观察到了延续效应，从而分析了第 1 期的数据。LNDP 摄入比安慰剂导致更高的处理速度、执行功能和认知灵活性。因此，单次服用 LNDP 片剂补充剂可能会改善认知功能，包括日常生活中的记忆、注意力、集中力和信息处理。
