β-乳球蛋白增强健康成年人的神经活动，表现为事件相关 P300 波幅增大：一项随机对照试验。
β-Lactolin Enhances Neural Activity, Indicated by Event-Related P300 Amplitude, in Healthy Adults: A Randomized Controlled Trial.
机构信息
Kirin Central Research Institute, Kirin Holdings Company, Ltd., Fujisawa, Kanagawa, Japan.
Department of Psychology, Keio University, Mita, Minato-ku, Tokyo, Japan.
出版信息
J Alzheimers Dis. 2021;81(2):787-796. doi: 10.3233/JAD-201413.
BACKGROUND
Epidemiological studies have shown that dairy product consumption is beneficial for cognitive function in elderly individuals. β-lactolin is a Gly-Thr-Trp-Tyr lacto-tetrapeptide rich in fermented dairy products that improves memory retrieval, attention, and executive function in older adults with subjective cognitive decline and prevents the pathology of Alzheimer's disease in rodents. There has been no study on the effects of β-lactolin on neural activity in humans.
OBJECTIVE
We investigated the effects of β-lactolin on neural activity and cognitive function in healthy adults.
METHODS
In this randomized, double-blind, placebo-controlled study, 30 participants (45-64 years old) consumed β-lactolin or placebo for 6 weeks. Neural activity during auditory and language tasks was measured through 64-channel electroencephalography. Moreover, verbal fluency tests were performed at baseline and after 6 weeks.
RESULTS
The β-lactolin group had a significantly higher P300 amplitude at the Cp2 site (a part of the parietal lobe near the center of brain, p = 0.011), and C4 site (the area between the frontal and parietal lobe, p = 0.02) during the auditory tasks after 6 weeks than the placebo group. Thus, β-lactolin supplementation promoted neural activity in the parietal area, which increases concentration and attention during auditory cognitive tasks. Compared with the placebo group, the β-lactolin group also showed significant changes in the scores of verbal fluency test after 6 weeks (p = 0.033).
CONCLUSION
Our findings provide insight into the mechanisms underlying the effects of β-lactolin on attention in healthy adults.
背景
流行病学研究表明，乳制品的摄入对老年人的认知功能有益。β-乳球蛋白是一种富含发酵乳制品的 Gly-Thr-Trp-Tyr 四肽，可改善有主观认知下降的老年人的记忆检索、注意力和执行功能，并可预防啮齿动物的阿尔茨海默病病理学。目前尚未有研究探讨β-乳球蛋白对人类神经活动的影响。
目的
我们研究了β-乳球蛋白对健康成年人神经活动和认知功能的影响。
方法
在这项随机、双盲、安慰剂对照研究中，30 名参与者（45-64 岁）分别服用β-乳球蛋白或安慰剂，持续 6 周。通过 64 通道脑电图测量听觉和语言任务期间的神经活动。此外，在基线和 6 周后进行言语流畅性测试。
结果
β-乳球蛋白组在 6 周后听觉任务时，Cp2 （靠近大脑中心的顶叶部分）和 C4 （额顶叶之间的区域）的 P300 振幅显著升高（p=0.011 和 p=0.02），而安慰剂组没有。因此，β-乳球蛋白补充剂促进了顶叶区域的神经活动，增加了听觉认知任务期间的注意力和注意力。与安慰剂组相比，β-乳球蛋白组在 6 周后言语流畅性测试的评分也有显著变化（p=0.033）。
结论
我们的研究结果为β-乳球蛋白对健康成年人注意力的影响机制提供了新的见解。
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