Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Department of Food Science and Human Nutrition, University of Florida College of Agricultural and Life Sciences, Gainesville, FL, 32611, USA.
Curr Nutr Rep. 2021 Mar;10(1):58-70. doi: 10.1007/s13668-021-00351-7. Epub 2021 Feb 13.
The purpose of this review was to investigate and synthesize psychosocial outcomes from pharmacotherapy experimental trials for weight loss among adolescents with obesity.
There is a paucity of research regarding pharmacological interventions for adolescents with obesity. These studies have typically reported reductions in weight, and side effects have been inconsistently described. Overall, medication seems to be a safe and effective obesity treatment modality for adolescents with obesity. Six articles were included in this review. Studies varied in medication type, medication dosing, lifestyle components, psychosocial measures, measurement intervals, and psychosocial outcomes. All studies found a reduction in weight and/or BMI. Studies were often underpowered to detect differences in psychosocial variables, which were always considered secondary or exploratory outcomes. Future research should include psychosocial outcomes as a primary endpoint of pharmacological interventions for adolescent obesity. Ultimately, the treatment of the complex disease of obesity deserves to be assessed through multiple health domains extending beyond weight reduction.
综述目的：本综述旨在研究和综合抗肥胖药物治疗青少年减肥的心理社会结果。
最新发现：针对肥胖青少年的药理学干预措施研究甚少。这些研究通常报告体重减轻，而副作用的描述不一致。总的来说，药物治疗似乎是肥胖青少年安全有效的肥胖治疗方法。本综述共纳入 6 篇文章。研究中药物类型、药物剂量、生活方式成分、心理社会测量、测量间隔和心理社会结果各不相同。所有研究都发现体重和/或 BMI 降低。由于研究通常没有足够的效力来检测心理社会变量的差异，这些变量总是被认为是次要或探索性的结果。未来的研究应将心理社会结果作为青少年肥胖药物干预的主要终点。最终，肥胖这一复杂疾病的治疗值得通过多个健康领域进行评估，而不仅仅是体重减轻。
