Nanomaterial Research Laboratory [NMRL], Nano Division, Yenepoya Research Centre, Yenepoya [Deemed to be University], Deralakatte, Mangalore 575 018, India.
Department of Ophthalmology, Yenepoya Medical College, Yenepoya [Deemed to be University], Deralakatte, Mangalore 575 018, India.
Int J Biol Macromol. 2021 Apr 15;176:47-65. doi: 10.1016/j.ijbiomac.2021.02.057. Epub 2021 Feb 10.
Most of the people in the world are affected by glaucoma, which leads to irreversible blindness. Several patient friendly treatments are available, nevertheless medications lack an easy and efficient way of sustained delivery. To make the delivery with enhanced bioavailability, biodegradable and non-biodegradable polymers-based drug carriers are explored. However, ocular drug delivery issues have not been resolved yet due to less adhesiveness, poor penetration ability, pH, and temperature dependent burst releases. Chitosan is found to be effective for ocular drug delivery due to excellent physio-chemical properties in terms of overcoming the existing issues. In this review, we aim to highlight why it has been chosen and the holy grail for ocular drug delivery. Besides, we have comprehensively reviewed recent patents on chitosan as a platform for ocular drug delivery and future perspectives on factors, lacunae and challenges that need to be addressed for better ocular delivery methods for glaucoma management.
世界上大多数人都受到青光眼的影响，而青光眼会导致不可逆转的失明。目前已有几种适合患者的治疗方法，但药物缺乏一种简单有效的持续输送方式。为了提高生物利用度，正在探索基于可生物降解和不可生物降解聚合物的药物载体。然而，由于黏附性差、渗透能力差、pH 值和温度依赖性的爆发释放等问题，眼部药物输送问题仍未得到解决。壳聚糖由于在克服现有问题方面具有出色的物理化学性质，因此被证明对眼部药物输送有效。在这篇综述中，我们旨在强调为什么选择壳聚糖以及它作为眼部药物输送的圣杯。此外，我们还全面回顾了壳聚糖作为眼部药物输送平台的最新专利，以及未来需要解决的因素、空白和挑战，以改善青光眼管理的眼部输送方法。
