Pramanik Sheersha, Aggarwal Akanksha, Kadi Ammar, Alhomrani Majid, Alamri Abdulhakeem S, Alsanie Walaa F, Koul Kanchan, Deepak A, Bellucci Stefano
Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras Chennai 600036 Tamil Nadu India.
Department of Biotechnology, Indian Institute of Technology Hyderabad Kandi Sangareddy Telangana 502284 India.
RSC Adv. 2024 Jun 17;14(27):19219-19256. doi: 10.1039/d4ra01594k. eCollection 2024 Jun 12.
Chitosan, a biopolymer acquired from chitin, has emerged as a versatile and favorable material in the domain of tissue engineering and wound healing. Its biocompatibility, biodegradability, and antimicrobial characteristics make it a suitable candidate for these applications. In tissue engineering, chitosan-based formulations have garnered substantial attention as they have the ability to mimic the extracellular matrix, furnishing an optimal microenvironment for cell adhesion, proliferation, and differentiation. In the realm of wound healing, chitosan-based dressings have revealed exceptional characteristics. They maintain a moist wound environment, expedite wound closure, and prevent infections. These formulations provide controlled release mechanisms, assuring sustained delivery of bioactive molecules to the wound area. Chitosan's immunomodulatory properties have also been investigated to govern the inflammatory reaction during wound healing, fostering a balanced healing procedure. In summary, recent progress in chitosan-based formulations portrays a substantial stride in tissue engineering and wound healing. These innovative approaches hold great promise for enhancing patient outcomes, diminishing healing times, and minimizing complications in clinical settings. Continued research and development in this field are anticipated to lead to even more sophisticated chitosan-based formulations for tissue repair and wound management. The integration of chitosan with emergent technologies emphasizes its potential as a cornerstone in the future of regenerative medicine and wound care. Initially, this review provides an outline of sources and unique properties of chitosan, followed by recent signs of progress in chitosan-based formulations for tissue engineering and wound healing, underscoring their potential and innovative strategies.
壳聚糖是一种从几丁质中提取的生物聚合物，已成为组织工程和伤口愈合领域中一种用途广泛且有利的材料。它的生物相容性、生物降解性和抗菌特性使其成为这些应用的合适候选材料。在组织工程中，基于壳聚糖的制剂备受关注，因为它们能够模拟细胞外基质，为细胞黏附、增殖和分化提供最佳的微环境。在伤口愈合领域，基于壳聚糖的敷料展现出卓越的特性。它们能维持伤口的湿润环境，加速伤口愈合，并预防感染。这些制剂提供控释机制，确保生物活性分子持续递送至伤口区域。壳聚糖的免疫调节特性也已得到研究，以控制伤口愈合过程中的炎症反应，促进愈合过程的平衡。总之，基于壳聚糖的制剂的最新进展表明在组织工程和伤口愈合方面取得了重大进展。这些创新方法在改善患者预后、缩短愈合时间以及减少临床并发症方面具有巨大潜力。预计该领域的持续研发将带来更先进的基于壳聚糖的组织修复和伤口管理制剂。壳聚糖与新兴技术的整合凸显了其作为再生医学和伤口护理未来基石的潜力。本文首先概述壳聚糖的来源和独特性质，接着阐述基于壳聚糖的组织工程和伤口愈合制剂的最新进展迹象，强调其潜力和创新策略。
