Department of Biomedical Sciences, University of Padua, Italy.
Cell Calcium. 2021 May;95:102354. doi: 10.1016/j.ceca.2021.102354. Epub 2021 Feb 6.
Both Ca and reactive oxygen species (ROS) are double face entities, acting as signaling messengers or cell fate determinants according to their concentration and to spatial temporal restrictions. Recently, Beretta and colleagues found that ROS generated at ER-mitochondria contact sites (MAMs) support cell survival in stress conditions by decreasing inter-organelle Ca transfer.
钙（Ca）和活性氧物种（ROS）都是双刃剑，根据其浓度和时空限制，它们可以作为信号传递者或细胞命运决定因子发挥作用。最近，Beretta 及其同事发现，在应激条件下，在 ER-线粒体接触位点（MAMs）产生的 ROS 通过减少细胞器间的 Ca 转移来支持细胞存活。
